The mouse prefrontal cortex: Unity in diversity.

Animals Cognition / physiology Electrophysiological Phenomena Gene Expression Profiling Mice Models, Animal Neural Pathways / physiology Neurons / physiology Prefrontal Cortex / anatomy & histology Transcriptome

Journal

Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320

Informations de publication

Date de publication:
16 06 2021
Historique:
received: 13 11 2020
revised: 28 01 2021
accepted: 29 03 2021
pubmed: 25 4 2021
medline: 21 7 2021
entrez: 24 4 2021
Statut: ppublish

Résumé

The prefrontal cortex (PFC) is considered to constitute the highest stage of neural integration and to be devoted to representation and production of actions. Studies in primates have laid the foundation for theories regarding the principles of prefrontal function and provided mechanistic insights. The recent surge of studies of the PFC in mice holds promise for evolvement of present theories and development of novel concepts, particularly regarding principles shared across mammals. Here we review recent empirical work on the mouse PFC capitalizing on the experimental toolbox currently privileged to studies in this species. We conclude that this line of research has revealed cellular and structural distinctions of the PFC and neuronal activity with direct relevance to theories regarding the functions of the PFC. We foresee that data-rich mouse studies will be key to shed light on the general prefrontal architecture and mechanisms underlying cognitive aspects of organized actions.

Identifiants

DOI: 10.1016/j.neuron.2021.03.035 PMID: 33894133
pubmed: 33894133
pii: S0896-6273(21)00205-1
doi: 10.1016/j.neuron.2021.03.035
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1925-1944

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Pierre Le Merre (P)

Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.

Sofie Ährlund-Richter (S)

Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.

Marie Carlén (M)

Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden; Department of Biosciences and Nutrition, Karolinska Institutet, 141 83 Huddinge, Sweden. Electronic address: marie.carlen@ki.se.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The mouse prefrontal cortex: Unity in diversity.
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › The mouse prefrontal cortex: Unity in diversity.
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes électrophysiologiques › The mouse prefrontal cortex: Unity in diversity.
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › The mouse prefrontal cortex: Unity in diversity.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The mouse prefrontal cortex: Unity in diversity.
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › The mouse prefrontal cortex: Unity in diversity.
questionsmedicales.fr › Système nerveux › Voies nerveuses › The mouse prefrontal cortex: Unity in diversity.
questionsmedicales.fr › Cellules › Neurones › The mouse prefrontal cortex: Unity in diversity.
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Lobe frontal › Cortex préfrontal › The mouse prefrontal cortex: Unity in diversity.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › The mouse prefrontal cortex: Unity in diversity.