Tau aggregation and increased neuroinflammation in athletes after sports-related concussions and in traumatic brain injury patients - A PET/MR study.
Inflammation
Positron emission tomography (PET)
Sports-related concussion
Tau
Traumatic brain injury
Journal
NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070
Informations de publication
Date de publication:
2021
2021
Historique:
received:
24
10
2020
revised:
11
02
2021
accepted:
02
04
2021
pubmed:
25
4
2021
medline:
31
7
2021
entrez:
24
4
2021
Statut:
ppublish
Résumé
Traumatic brain injury (TBI) and repeated sports-related concussions (rSRCs) are associated with an increased risk for neurodegeneration. Autopsy findings of selected cohorts of long-term TBI survivors and rSRC athletes reveal increased tau aggregation and a persistent neuroinflammation. To assess in vivo tau aggregation and neuroinflammation in young adult TBI and rSRC cohorts, we evaluated 9 healthy controls (mean age 26 ± 5 years; 4 males, 5 females), 12 symptomatic athletes (26 ± 7 years; 6 males, 6 females) attaining ≥3 previous SRCs, and 6 moderate-to severe TBI patients (27 ± 7 years; 4 males, 2 females) in a combined positron emission tomography (PET)/magnetic resonance (MR) scanner ≥6 months post-injury. Dual PET tracers, [
Identifiants
pubmed: 33894460
pii: S2213-1582(21)00109-1
doi: 10.1016/j.nicl.2021.102665
pmc: PMC8091173
pii:
doi:
Substances chimiques
tau Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102665Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.