The effects of Pythagorean Self-Awareness Intervention on patients with major depressive disorder: A pilot randomized controlled trial.

Adult Anxiety Depression Depressive Disorder, Major / therapy Humans Hydrocortisone Pilot Projects Quality of Life
Cortisol Depression Major depressive disorder Pilot randomized clinical trial Pythagorean self-awareness Stress

Journal

Journal of psychiatric research
ISSN: 1879-1379
Titre abrégé: J Psychiatr Res
Pays: England
ID NLM: 0376331

Informations de publication

Date de publication:
06 2021
Historique:
received: 28 10 2020
revised: 26 03 2021
accepted: 31 03 2021
pubmed: 25 4 2021
medline: 6 7 2021
entrez: 24 4 2021
Statut: ppublish

Résumé

Stress plays an important role in major depressive disorder (MDD). Thus, a variety of stress management programs have been developed for people with this diagnosis. This is a pilot randomized clinical trial which implemented a holistic stress management program, Pythagorean Self-Awareness Intervention (PSAI) in adults with MDD, aiming to evaluate the effectiveness of PSAI compared to standard care for reduction of depressive symptoms (primary aim), improving mental health and quality of life (secondary aims). A total of 69 participants were randomized to an intervention group (N = 34), who received the usual care provided for patients with major depression and attended the PSAI program, and a control group (N = 35), who received the usual care only. Measurements were taken in both groups before and after the intervention and included: 1. Self-report questionnaires for measuring depressive symptoms, healthy lifestyle, perceived stress, anxiety, positive and negative affect and sleep quality, 2 Cognitive function assessment tools, 3. Hair and salivary cortisol. The intervention group demonstrated significantly greater reductions in depressive symptoms, negative affect, perceived stress, sleep quality and significantly greater increase in visual memory and healthy lifestyle compared to the control group. In addition, the intervention group demonstrated a significant reduction in first morning salivary cortisol, indicating a reduction in diurnal stress levels, while no significant change of salivary cortisol was observed in the control group. Finally, none of the study's groups demonstrated a significant change in hair cortisol concentration. In conclusion, PSAI can be applied to adults suffering from MDD with significant benefits for their mental health and quality of life. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04536714.

Identifiants

DOI: 10.1016/j.jpsychires.2021.03.067 PMID: 33894540
pubmed: 33894540
pii: S0022-3956(21)00222-3
doi: 10.1016/j.jpsychires.2021.03.067
pii:
doi:

Substances chimiques

Hydrocortisone WI4X0X7BPJ

Banques de données

ClinicalTrials.gov
['NCT04536714']

Types de publication

Journal Article Randomized Controlled Trial

Langues

eng

Sous-ensembles de citation

IM

Pagination

326-334

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Evgenia E Psarraki (EE)

School of Medicine, National and Kapodistrian University of Athens, 4 Soranou Ephessiou Street, 11527, Athens, Greece. Electronic address: jennyps92@gmail.com.

Flora Bacopoulou (F)

Center for Adolescent Medicine and UNESCO Chair on Adolescent Health Care, First Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Aghia Sophia Children's Hospital, 1 Thivon Street, Goudi, 11527, Athens, Greece; University Research Institute of Maternal and Child Health & Precision Medicine, and UNESCO Chair on Adolescent Health Care, National and Kapodistrian University of Athens, Aghia Sophia Children's Hospital, 8 Livadias Street, Goudi, 11527, Athens, Greece.

Eustathios Panagoulias (E)

Mental Health Center of Peristeri, Department of the Psychiatric Hospital of Attica, Ploutonos 19, Peristeri, 12135, Athens, Greece.

Maria Michou (M)

School of Medicine, National and Kapodistrian University of Athens, 4 Soranou Ephessiou Street, 11527, Athens, Greece; Human Ecology Laboratory, Department of Home Economics and Ecology, Harokopio University, 70 El. Venizelou Ave, 17671, Kallithea, Athens, Greece.

Panagiotis Pelekasis (P)

School of Medicine, National and Kapodistrian University of Athens, 4 Soranou Ephessiou Street, 11527, Athens, Greece.

Artemios Artemiadis (A)

Department of Neurology, Medical School, University of Cyprus, Shakolas Educational Center, Old Road Nikosia-Limmasol 215/6, 2029 Aglantzia, Nicosia, Cyprus.

George P Chrousos (GP)

School of Medicine, National and Kapodistrian University of Athens, 4 Soranou Ephessiou Street, 11527, Athens, Greece; Center for Adolescent Medicine and UNESCO Chair on Adolescent Health Care, First Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Aghia Sophia Children's Hospital, 1 Thivon Street, Goudi, 11527, Athens, Greece; University Research Institute of Maternal and Child Health & Precision Medicine, and UNESCO Chair on Adolescent Health Care, National and Kapodistrian University of Athens, Aghia Sophia Children's Hospital, 8 Livadias Street, Goudi, 11527, Athens, Greece.

Christina Darviri (C)

School of Medicine, National and Kapodistrian University of Athens, 4 Soranou Ephessiou Street, 11527, Athens, Greece.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › The effects of Pythagorean Self-Awareness...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Anxiété › The effects of Pythagorean Self-Awareness...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Dépression › The effects of Pythagorean Self-Awareness...
questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Trouble dépressif › Trouble dépressif majeur › The effects of Pythagorean Self-Awareness...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The effects of Pythagorean Self-Awareness...
questionsmedicales.fr › Hormones corticosurrénaliennes › Hydroxycorticostéroïdes › 17-Hydroxycorticostéroïdes › Hydrocortisone › The effects of Pythagorean Self-Awareness...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Projets pilotes › The effects of Pythagorean Self-Awareness...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Qualité de vie › The effects of Pythagorean Self-Awareness...