Metallobiochemistry of ultratrace levels of bismuth in the rat I. Metabolic patterns of
Bismuth
Environmental toxicology
Metabolic pattern
Radioisotopes
Rat blood
Journal
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
ISSN: 1878-3252
Titre abrégé: J Trace Elem Med Biol
Pays: Germany
ID NLM: 9508274
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
13
10
2020
revised:
22
02
2021
accepted:
12
04
2021
pubmed:
26
4
2021
medline:
17
2
2022
entrez:
25
4
2021
Statut:
ppublish
Résumé
The number of the applications of bismuth (Bi) is rapidly and remarkably increasing, enhancing the chance to increase the levels to which humans are normally daily exposed. The interest to Bi comes also from the potential of Bi-based nanoparticles (BiNPs) for industrial and biomedical purposes. Like other metal-based NPs used in nanomedicine, BiNPs may release ultratrace amounts of Bi ions when injected. The metabolic fate and toxicity of these ions still needs to be evaluated. At present, knowledge of Bi metabolism in laboratory animals refers almost solely to studies under unnatural "extreme" exposures, i.e. pharmacologically relevant high-doses (up to thousand mg kg Rats were intraperitoneally injected with 0.8 μg Bi kg 24 h after the administration, the blood concentration of Bi was 0.18 ng mL On the basis of an environmental biochemical toxicology approach, we have undertaken a study on the metabolic patterns of Bi
Sections du résumé
BACKGROUND
BACKGROUND
The number of the applications of bismuth (Bi) is rapidly and remarkably increasing, enhancing the chance to increase the levels to which humans are normally daily exposed. The interest to Bi comes also from the potential of Bi-based nanoparticles (BiNPs) for industrial and biomedical purposes. Like other metal-based NPs used in nanomedicine, BiNPs may release ultratrace amounts of Bi ions when injected. The metabolic fate and toxicity of these ions still needs to be evaluated. At present, knowledge of Bi metabolism in laboratory animals refers almost solely to studies under unnatural "extreme" exposures, i.e. pharmacologically relevant high-doses (up to thousand mg kg
METHODOLOGY
METHODS
Rats were intraperitoneally injected with 0.8 μg Bi kg
RESULTS
RESULTS
24 h after the administration, the blood concentration of Bi was 0.18 ng mL
CONCLUSIONS
CONCLUSIONS
On the basis of an environmental biochemical toxicology approach, we have undertaken a study on the metabolic patterns of Bi
Identifiants
pubmed: 33895056
pii: S0946-672X(21)00050-X
doi: 10.1016/j.jtemb.2021.126760
pii:
doi:
Substances chimiques
Transferrin
0
Iron
E1UOL152H7
Bismuth
U015TT5I8H
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
126760Informations de copyright
Copyright © 2021 Elsevier GmbH. All rights reserved.