Genetic epidemiology of SARS-CoV-2 transmission in renal dialysis units - A high risk community-hospital interface.
COVID-19
Haemodialysis
Infection control
Nosocomial
Outbreak
Rapid sequencing
Renal dialysis unit
SARS-CoV-2
Journal
The Journal of infection
ISSN: 1532-2742
Titre abrégé: J Infect
Pays: England
ID NLM: 7908424
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
21
03
2021
accepted:
18
04
2021
pubmed:
26
4
2021
medline:
25
6
2021
entrez:
25
4
2021
Statut:
ppublish
Résumé
Patients requiring haemodialysis are at increased risk of serious illness with SARS-CoV-2 infection. To improve the understanding of transmission risks in six Scottish renal dialysis units, we utilised the rapid whole-genome sequencing data generated by the COG-UK consortium. We combined geographical, temporal and genomic sequence data from the community and hospital to estimate the probability of infection originating from within the dialysis unit, the hospital or the community using Bayesian statistical modelling and compared these results to the details of epidemiological investigations. Of 671 patients, 60 (8.9%) became infected with SARS-CoV-2, of whom 16 (27%) died. Within-unit and community transmission were both evident and an instance of transmission from the wider hospital setting was also demonstrated. Near-real-time SARS-CoV-2 sequencing data can facilitate tailored infection prevention and control measures, which can be targeted at reducing risk in these settings.
Identifiants
pubmed: 33895226
pii: S0163-4453(21)00206-1
doi: 10.1016/j.jinf.2021.04.020
pmc: PMC8061788
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
96-103Subventions
Organisme : Medical Research Council
ID : MC_UU_12014/12
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19026
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12014/9
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19027
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
Transpl Immunol. 2019 Apr;53:51-60
pubmed: 30664927
JAMA. 2020 Mar 17;323(11):1061-1069
pubmed: 32031570
Bioinformatics. 2010 Mar 1;26(5):589-95
pubmed: 20080505
Nat Med. 2020 Sep;26(9):1405-1410
pubmed: 32678356
Nat Protoc. 2017 Jun;12(6):1261-1276
pubmed: 28538739
Ann Intern Med. 2020 May 5;172(9):577-582
pubmed: 32150748
Elife. 2021 Jun 29;10:
pubmed: 34184637
Lancet Infect Dis. 2020 Nov;20(11):1263-1271
pubmed: 32679081
J Am Soc Nephrol. 2020 Jul;31(7):1409-1415
pubmed: 32467113
Nature. 2016 Feb 11;530(7589):228-232
pubmed: 26840485
J Am Soc Nephrol. 2020 Jul;31(7):1398-1408
pubmed: 32482688
ERJ Open Res. 2021 Jun 07;7(2):
pubmed: 34104643
BMJ. 2020 May 22;369:m1985
pubmed: 32444460
J Infect Dis. 2018 Sep 22;218(9):1485-1489
pubmed: 29873767
BMC Nephrol. 2020 Oct 1;21(1):419
pubmed: 33004002
Euro Surveill. 2020 Jan;25(3):
pubmed: 31992387
N Engl J Med. 2020 Feb 20;382(8):727-733
pubmed: 31978945
J Nephrol. 2020 Jun;33(3):401-403
pubmed: 32323202
Nat Rev Nephrol. 2020 Jun;16(6):311-313
pubmed: 32249840
Am J Transplant. 2020 Nov;20(11):3008-3018
pubmed: 32780493
J Nephrol. 2020 Apr;33(2):193-196
pubmed: 32207068
Lancet. 2020 Jul 25;396(10246):e6-e7
pubmed: 32653078
Clin J Am Soc Nephrol. 2020 Aug 7;15(8):1139-1145
pubmed: 32444393
G Ital Nefrol. 2020 Apr 9;37(2):
pubmed: 32281757
Nephrol Dial Transplant. 2016 Dec;31(12):2041-2048
pubmed: 27190373
Genome Biol. 2019 Jan 8;20(1):8
pubmed: 30621750
J Clin Microbiol. 2015 Jul;53(7):2230-7
pubmed: 25972414
Nature. 2020 Mar;579(7798):265-269
pubmed: 32015508