Evidence update for the treatment of anaphylaxis.
Adrenaline
Anaphylaxis
Antihistamine
Corticosteroids
Resuscitation
Journal
Resuscitation
ISSN: 1873-1570
Titre abrégé: Resuscitation
Pays: Ireland
ID NLM: 0332173
Informations de publication
Date de publication:
23 Apr 2021
23 Apr 2021
Historique:
received:
24
01
2021
revised:
10
03
2021
accepted:
12
04
2021
pubmed:
26
4
2021
medline:
26
4
2021
entrez:
25
4
2021
Statut:
aheadofprint
Résumé
The Resuscitation Council UK has updated its Guideline for healthcare providers on the Emergency treatment of anaphylaxis. As part of this process, an evidence review was undertaken by the Guideline Working Group, using an internationally-accepted approach for adoption, adaptation, and de novo guideline development based on the Grading of Recommendations Assessment, Development and Evaluation (GRADE) evidence to decision (EtD) framework, referred to as GRADE-ADOLOPMENT. A number of significant changes have been made, which will be reflected in the updated Guideline. These include: emphasis on repeating intramuscular adrenaline doses after 5 min if symptoms of anaphylaxis do not resolve; corticosteroids (e.g. hydrocortisone) no longer being routinely recommended for the emergency treatment of anaphylaxis; interventions for reactions which are refractory to initial treatment with adrenaline; a recommendation against the use of antihistamines for the acute management of anaphylaxis; and guidance relating to the duration of observation following anaphylaxis, and timing of discharge.
Identifiants
pubmed: 33895231
pii: S0300-9572(21)00150-7
doi: 10.1016/j.resuscitation.2021.04.010
pmc: PMC8139870
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
86-96Subventions
Organisme : Medical Research Council
ID : MR/K010468/1
Pays : United Kingdom
Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors report no declarations of interest.
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