A trio of quinoline-isoniazid-phthalimide with promising antiplasmodial potential: Synthesis, in-vitro evaluation and heme-polymerization inhibition studies.

Animals Antimalarials / chemical synthesis Chlorocebus aethiops Heme / chemistry In Vitro Techniques Isoniazid / chemistry Phthalimides / chemistry Plasmodium falciparum / drug effects Polymerization / drug effects Quinolines / chemistry Structure-Activity Relationship Vero Cells
Antiplasmodial Cytotoxicity Heme-binding studies Quinoline-isoniazid-phthalimide triads

Journal

Bioorganic & medicinal chemistry
ISSN: 1464-3391
Titre abrégé: Bioorg Med Chem
Pays: England
ID NLM: 9413298

Informations de publication

Date de publication:
01 06 2021
Historique:
received: 31 12 2020
revised: 31 03 2021
accepted: 06 04 2021
pubmed: 26 4 2021
medline: 10 11 2021
entrez: 25 4 2021
Statut: ppublish

Résumé

Quinoline-isoniazid-phthalimide triads have been synthesised to assess their antiplasmodial efficacy and cytotoxicity against chloroquine-resistant W2 strain of P. falciparum and Vero cells, respectively. Most of the synthesized compounds displayed IC

Identifiants

DOI: 10.1016/j.bmc.2021.116159 PMID: 33895706
pubmed: 33895706
pii: S0968-0896(21)00167-X
doi: 10.1016/j.bmc.2021.116159
pii:
doi:

Substances chimiques

Antimalarials 0
Phthalimides 0
Quinolines 0
Heme 42VZT0U6YR
Isoniazid V83O1VOZ8L

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

116159

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Anu Rani (A)

Department of Chemistry, Guru Nanak Dev University, Amritsar 143005, Punjab, India.

Anny Sharma (A)

Department of Chemistry, Guru Nanak Dev University, Amritsar 143005, Punjab, India.

Jenny Legac (J)

Department of Medicine, University of California, San Francisco, CA, USA.

Philip J Rosenthal (PJ)

Department of Medicine, University of California, San Francisco, CA, USA.

Parvesh Singh (P)

School of Chemistry and Physics, University of KwaZulu-Natal, P/Bag X54001, Westville, Durban, South Africa.

Vipan Kumar (V)

Department of Chemistry, Guru Nanak Dev University, Amritsar 143005, Punjab, India. Electronic address: vipan_org@yahoo.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A trio of quinoline-isoniazid-phthalimide with...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Antipaludiques › A trio of quinoline-isoniazid-phthalimide with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Cercopithecus › Cercopithecus aethiops › A trio of quinoline-isoniazid-phthalimide with...
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Porphyrines › Métalloporphyrines › Hème › A trio of quinoline-isoniazid-phthalimide with...
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › A trio of quinoline-isoniazid-phthalimide with...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Acides isonicotiniques › Isoniazide › A trio of quinoline-isoniazid-phthalimide with...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Isoindoles › Phtalimides › A trio of quinoline-isoniazid-phthalimide with...
questionsmedicales.fr › Eucaryotes › Alveolata › Apicomplexa › Haemosporida › Plasmodium › Plasmodium falciparum › A trio of quinoline-isoniazid-phthalimide with...
questionsmedicales.fr › Phénomènes chimiques › Polymérisation › A trio of quinoline-isoniazid-phthalimide with...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › A trio of quinoline-isoniazid-phthalimide with...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › A trio of quinoline-isoniazid-phthalimide with...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules Vero › A trio of quinoline-isoniazid-phthalimide with...