Design, synthesis and
Amides
/ chemical synthesis
Amidohydrolases
/ antagonists & inhibitors
Analgesics
/ chemical synthesis
Animals
Cyclooxygenase 2
/ metabolism
Dose-Response Relationship, Drug
Drug Design
Enzyme Inhibitors
/ chemical synthesis
Flurbiprofen
/ chemical synthesis
Male
Mice
Mice, Inbred Strains
Models, Molecular
Molecular Structure
Quantum Theory
Rats
Rats, Sprague-Dawley
Rats, Wistar
Static Electricity
Structure-Activity Relationship
FAAH inhibition
Flurbiprofen amides
allodynia
cyclooxygenase
endocannabinoid
fatty acid amide hydrolase
hyperalgesia
non-steroidal anti-inflammatory drugs
Journal
Journal of enzyme inhibition and medicinal chemistry
ISSN: 1475-6374
Titre abrégé: J Enzyme Inhib Med Chem
Pays: England
ID NLM: 101150203
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
entrez:
26
4
2021
pubmed:
27
4
2021
medline:
7
8
2021
Statut:
ppublish
Résumé
Compounds combining dual inhibitory action against FAAH and cyclooxygenase (COX) may be potentially useful analgesics. Here, we describe a novel flurbiprofen analogue, N-(3-bromopyridin-2-yl)-2-(2-fluoro-(1,1'-biphenyl)-4-yl)propanamide (
Identifiants
pubmed: 33896320
doi: 10.1080/14756366.2021.1875459
pmc: PMC8079065
doi:
Substances chimiques
Amides
0
Analgesics
0
Enzyme Inhibitors
0
Flurbiprofen
5GRO578KLP
Cyclooxygenase 2
EC 1.14.99.1
Amidohydrolases
EC 3.5.-
fatty-acid amide hydrolase
EC 3.5.1.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
940-953Références
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