Challenges in diagnosis and management of adult spinal cord gliomas.
Astrocytoma
Ependymoma
Magnetic resonance imaging
Molecular markers
Spinal cord glioma
Journal
Revue neurologique
ISSN: 0035-3787
Titre abrégé: Rev Neurol (Paris)
Pays: France
ID NLM: 2984779R
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
06
07
2020
revised:
09
02
2021
accepted:
09
02
2021
pubmed:
27
4
2021
medline:
30
7
2021
entrez:
26
4
2021
Statut:
ppublish
Résumé
Intramedullary spinal cord gliomas have very low incidence rates. They are associated with difficulties in diagnosis and treatment, and cause significant morbidity. Their clinical presentation and their appearance at magnetic resonance imaging are not specific. They can mimic inflammatory, infectious, vascular disorders or other neoplastic lesions. Primary treatment is surgery. Surgical resection can often be total for ependymomas, but difficult for infiltrating astrocytomas. Radiotherapy is indicated for malignant tumors, but remains controversial in some indications. Chemotherapy is reserved for recurrence, but small retrospective series are available. Genetic studies have revealed genetic alterations which could have a potential impact on treatment in the near future.
Identifiants
pubmed: 33896651
pii: S0035-3787(21)00506-3
doi: 10.1016/j.neurol.2021.02.384
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
515-523Informations de copyright
Copyright © 2021. Published by Elsevier Masson SAS.