Early Transformation to Classic Hodgkin Lymphoma in a Chemotherapy-naïve Chronic Lymphocytic Leukemia Patient upon Initial Treatment with Ibrutinib.
CLL
Richter's transformation
ibrutinib
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
15 Oct 2021
15 Oct 2021
Historique:
pubmed:
27
4
2021
medline:
21
10
2021
entrez:
26
4
2021
Statut:
ppublish
Résumé
A 71-year-old woman with a four-year history of chronic lymphocytic leukemia (CLL) received ibrutinib as initial treatment due to progressive anemia and thrombocytopenia. Eleven months after the start of the treatments, although her cytopenia had ameliorated, she developed classic Hodgkin lymphoma, a rare form of Richter's transformation. She was successfully treated with two courses of adriamycin, vinblastin, bleomycin and dacarbazine followed by radiotherapy. In general, several clinical, genetic and molecular factors are associated with Richter's transformation. In addition, our present case suggested that ibrutinib could be a potential risk factor for Richter's transformation in CLL patients.
Identifiants
pubmed: 33896865
doi: 10.2169/internalmedicine.6979-20
pmc: PMC8580765
doi:
Substances chimiques
Piperidines
0
Pyrazoles
0
Pyrimidines
0
ibrutinib
1X70OSD4VX
Adenine
JAC85A2161
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3305-3308Références
N Engl J Med. 2015 Dec 17;373(25):2425-37
pubmed: 26639149
Eur J Haematol. 2017 Oct;99(4):378-380
pubmed: 28561533
Br J Haematol. 2012 Jan;156(1):50-66
pubmed: 22017478
Blood. 2018 Jun 21;131(25):2745-2760
pubmed: 29540348
Leukemia. 2020 Dec;34(12):3197-3205
pubmed: 32704159
Nature. 2017 Feb 23;542(7642):489-493
pubmed: 28199309
N Engl J Med. 2013 Jul 4;369(1):32-42
pubmed: 23782158
Anticancer Res. 2017 Jun;37(6):3277-3280
pubmed: 28551676
JAMA Oncol. 2015 Apr;1(1):80-7
pubmed: 26182309
Blood. 2017 Nov 9;130(19):2151
pubmed: 29122775
Am J Hematol. 2015 Apr;90(4):334-8
pubmed: 25581025
Eur J Haematol. 2018 Apr;100(4):389-391
pubmed: 29243346
Adv Clin Exp Med. 2019 Aug;28(8):1051-1057
pubmed: 31199879
Ann Hematol. 2018 Jan;97(1):1-15
pubmed: 29063177
Leuk Lymphoma. 2019 Feb;60(2):519-522
pubmed: 29978754
Cancer. 2006 Sep 15;107(6):1294-302
pubmed: 16902984
Blood. 2017 Mar 16;129(11):1469-1479
pubmed: 28049639