[Intrahepatic cholestasis of pregnancy].
Schwangerschaftscholestase: In Zusammenarbeit mit der AG Geburtshilfe und Pränatalmedizin in der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe – Sektion Maternale Erkrankungen.
Bile acids and salts
Liver diseases
Pruritus
Stillbirth
Ursodeoxycholic acid
Journal
Der Gynakologe
ISSN: 0017-5994
Titre abrégé: Gynakologe
Pays: Germany
ID NLM: 0410275
Informations de publication
Date de publication:
2021
2021
Historique:
accepted:
08
03
2021
pubmed:
27
4
2021
medline:
27
4
2021
entrez:
26
4
2021
Statut:
ppublish
Résumé
Intrahepatic cholestasis of pregnancy (ICP) is the most frequent pregnancy-specific liver disease. It is characterized by pruritus and an accompanying elevation of serum bile acid concentrations and/or alanine aminotransferase (ALT), which are the key parameters in the diagnosis. Despite good maternal prognosis, elevated bile acid concentration in maternal blood is an influencing factor to advers fetal outcome. The ICP is associated with increased rates of preterm birth, neonatal unit admission and stillbirth. This is the result of acute fetal asphyxia as opposed to a chronic uteroplacental insufficiency. Reliable monitoring or predictive tools (e.g. cardiotocography (CTG) or ultrasound) that help to prevent advers events are yet to be explored. Medicinal treatment with ursodeoxycholic acid (UDCA) does not demonstrably reduce adverse perinatal outcomes but does improve pruritus and liver function test results. Bile acid concentrations and gestational age should be used as indications to determine delivery. There is a high risk of recurrence in subsequent pregnancies.
Identifiants
pubmed: 33896963
doi: 10.1007/s00129-021-04787-4
pii: 4787
pmc: PMC8056200
doi:
Types de publication
English Abstract
Journal Article
Langues
ger
Pagination
341-356Informations de copyright
© Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2021.
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