Validation of Induced Microglia-Like Cells (iMG Cells) for Future Studies of Brain Diseases.
Alzheimer's disease
RNA-seq profile
induced microglia-like cells (iMG cells)
peripheral blood mononuclear cells
phagocytosis
schizophrenia
synaptic pruning
Journal
Frontiers in cellular neuroscience
ISSN: 1662-5102
Titre abrégé: Front Cell Neurosci
Pays: Switzerland
ID NLM: 101477935
Informations de publication
Date de publication:
2021
2021
Historique:
received:
17
11
2020
accepted:
03
03
2021
entrez:
26
4
2021
pubmed:
27
4
2021
medline:
27
4
2021
Statut:
epublish
Résumé
Microglia are the primary resident immune cells of the central nervous system that maintain physiological homeostasis in the brain and contribute to the pathogenesis of many psychiatric disorders and neurodegenerative diseases. Due to the lack of appropriate human cellular models, it is difficult to study the basic pathophysiological processes linking microglia to brain diseases. In this study, we adopted a microglia-like cellular model derived from peripheral blood monocytes with granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-34 (IL-34). We characterized and validated this
Identifiants
pubmed: 33897370
doi: 10.3389/fncel.2021.629279
pmc: PMC8063054
doi:
Types de publication
Journal Article
Langues
eng
Pagination
629279Informations de copyright
Copyright © 2021 Banerjee, Lu, Do, Mize, Wu, Chen and Chen.
Déclaration de conflit d'intérêts
XC is employed by 410 AI, LLC. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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