Free Fatty Acid Receptors as Mediators and Therapeutic Targets in Liver Disease.
G protein-coupled receptor
fatty acid
free fatty acid receptor
intestinal failure-associated liver disease
liver disease
non-alcoholic fatty liver disease
non-alcoholic steatohepatitis
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2021
2021
Historique:
received:
20
01
2021
accepted:
15
03
2021
entrez:
26
4
2021
pubmed:
27
4
2021
medline:
27
4
2021
Statut:
epublish
Résumé
Free fatty acid receptors (FFARs) are a class of G protein-coupled receptors (GPCRs) that have wide-ranging effects on human physiology. The four well-characterized FFARs are FFAR1/GPR40, FFAR2/GPR43, FFAR3/GPR41, and FFAR4/GPR120. Short-chain (<6 carbon) fatty acids target FFAR2/GPR43 and FFAR3/GPR41. Medium- and long-chain fatty acids (6-12 and 13-21 carbon, respectively) target both FFAR1/GPR40 and FFAR4/GPR120. Signaling through FFARs has been implicated in non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), intestinal failure-associated liver disease (IFALD), and a variety of other liver disorders. FFARs are now regarded as targets for therapeutic intervention for liver disease, diabetes, obesity, hyperlipidemia, and metabolic syndrome. In this review, we provide an in-depth, focused summary of the role FFARs play in liver health and disease.
Identifiants
pubmed: 33897464
doi: 10.3389/fphys.2021.656441
pmc: PMC8058363
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
656441Informations de copyright
Copyright © 2021 Secor, Fligor, Tsikis, Yu and Puder.
Déclaration de conflit d'intérêts
MP is a consultant for Pronova/BASF, NorthSea Therapeutics, and has received research support from NorthSea Therapeutics, Otsuka Pharmaceutical Company, Alcresta, and Fresenius Kabi. Patent/Royalties for Omegaven are forthcoming. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
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