Epstein-Barr Virus Infection in the Development of Neurological Disorders.
CNS
Epstein-barr virus
PCNLS
encephalitis
latent infection
lytic infection
multiple sclerosis
Journal
Drug discovery today. Disease models
ISSN: 1740-6757
Titre abrégé: Drug Discov Today Dis Models
Pays: Netherlands
ID NLM: 101235079
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
26
4
2021
pubmed:
27
4
2021
medline:
27
4
2021
Statut:
ppublish
Résumé
Epstein-Barr Virus (EBV) is a ubiquitous human herpesvirus that contributes to the etiology of diverse human cancers and auto-immune diseases. EBV establishes a relatively benign, long-term latent infection in over 90 percent of the adult population. Yet, it also increases risk for certain cancers and auto-immune disorders depending on complex viral, host, and environmental factors that are only partly understood. EBV latent infection is found predominantly in memory B-cells, but the natural infection cycle and pathological aberrations enable EBV to infect numerous other cell types, including oral, nasopharyngeal, and gastric epithelia, B-, T-, and NK-lymphoid cells, myocytes, adipocytes, astrocytes, and neurons. EBV infected cells, free virus, and gene products can also be found in the CNS. In addition to the direct effects of EBV on infected cells and tissue, the effect of chronic EBV infection on the immune system is also thought to contribute to pathogenesis, especially auto-immune disease. Here, we review properties of EBV infection that may shed light on its potential pathogenic role in neurological disorders.
Identifiants
pubmed: 33897799
doi: 10.1016/j.ddmod.2020.01.001
pmc: PMC8059607
mid: NIHMS1564218
doi:
Types de publication
Journal Article
Langues
eng
Pagination
35-52Subventions
Organisme : NCI NIH HHS
ID : P30 CA010815
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA093606
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE017336
Pays : United States
Déclaration de conflit d'intérêts
Conflicts of Interest PML declares financial conflict of interest relationship with Cullinan Apollo, Inc. and ownership interest in Vironika, LLC.
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