Identifying key questions in the ecology and evolution of cancer.
cancer therapy
contemporary evolution
evolutionary medicine
genetics
neoplasm
species interactions
Journal
Evolutionary applications
ISSN: 1752-4571
Titre abrégé: Evol Appl
Pays: England
ID NLM: 101461828
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
27
10
2020
revised:
24
12
2020
accepted:
26
12
2020
entrez:
26
4
2021
pubmed:
27
4
2021
medline:
27
4
2021
Statut:
epublish
Résumé
The application of evolutionary and ecological principles to cancer prevention and treatment, as well as recognizing cancer as a selection force in nature, has gained impetus over the last 50 years. Following the initial theoretical approaches that combined knowledge from interdisciplinary fields, it became clear that using the eco-evolutionary framework is of key importance to understand cancer. We are now at a pivotal point where accumulating evidence starts to steer the future directions of the discipline and allows us to underpin the key challenges that remain to be addressed. Here, we aim to assess current advancements in the field and to suggest future directions for research. First, we summarize cancer research areas that, so far, have assimilated ecological and evolutionary principles into their approaches and illustrate their key importance. Then, we assembled 33 experts and identified 84 key questions, organized around nine major themes, to pave the foundations for research to come. We highlight the urgent need for broadening the portfolio of research directions to stimulate novel approaches at the interface of oncology and ecological and evolutionary sciences. We conclude that progressive and efficient cross-disciplinary collaborations that draw on the expertise of the fields of ecology, evolution and cancer are essential in order to efficiently address current and future questions about cancer.
Identifiants
pubmed: 33897809
doi: 10.1111/eva.13190
pii: EVA13190
pmc: PMC8061275
doi:
Types de publication
Journal Article
Langues
eng
Pagination
877-892Subventions
Organisme : BLRD VA
ID : I01 BX004495
Pays : United States
Organisme : NCI NIH HHS
ID : K22 CA226047
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG067584
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA217376
Pays : United States
Informations de copyright
© 2020 The Authors. Evolutionary Applications published by John Wiley & Sons Ltd.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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