Interplay between genetic, epigenetic, and gene expression variability: Considering complexity in evolvability.
DNA repair
cancer evolution
cell‐to‐cell heterogeneity
chromatin
stochastic gene expression
Journal
Evolutionary applications
ISSN: 1752-4571
Titre abrégé: Evol Appl
Pays: England
ID NLM: 101461828
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
19
11
2020
revised:
27
01
2021
accepted:
30
01
2021
entrez:
26
4
2021
pubmed:
27
4
2021
medline:
27
4
2021
Statut:
epublish
Résumé
Genetic variability, epigenetic variability, and gene expression variability (noise) are generally considered independently in their relationship with phenotypic variation. However, they appear to be intrinsically interconnected and influence it in combination. The study of the interplay between genetic and epigenetic variability has the longest history. This article rather considers the introduction of gene expression variability in its relationships with the two others and reviews for the first time experimental evidences over the four relationships connected to gene expression noise. They show how introducing this third source of variability complicates the way of thinking evolvability and the emergence of biological novelty. Finally, cancer cells are proposed to be an ideal model to decipher the dynamic interplay between genetic, epigenetic, and gene expression variability when one of them is either experimentally increased or therapeutically targeted. This interplay is also discussed in an evolutionary perspective in the context of cancer cell drug resistance.
Identifiants
pubmed: 33897810
doi: 10.1111/eva.13204
pii: EVA13204
pmc: PMC8061278
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
893-901Informations de copyright
© 2021 The Authors. Evolutionary Applications published by John Wiley & Sons Ltd.
Déclaration de conflit d'intérêts
None declared.
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