Chemically Engineered Immune Cell-Derived Microrobots and Biomimetic Nanoparticles: Emerging Biodiagnostic and Therapeutic Tools.
Animals
Autoimmune Diseases
/ immunology
Biomimetics
/ methods
Communicable Diseases
/ immunology
Drug Delivery Systems
/ methods
Exosomes
/ metabolism
Extracellular Vesicles
/ metabolism
Immunotherapy
/ methods
Inflammation
/ immunology
Mice
Nanomedicine
/ methods
Nanoparticles
/ administration & dosage
Neoplasms
/ immunology
artificial dendritic cell and extracellular vesicle
biomimetic drug delivery
engineered immune cell
immune cell membrane
nanomedicine
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
02
07
2020
revised:
26
11
2020
entrez:
26
4
2021
pubmed:
27
4
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Over the past decades, considerable attention has been dedicated to the exploitation of diverse immune cells as therapeutic and/or diagnostic cell-based microrobots for hard-to-treat disorders. To date, a plethora of therapeutics based on alive immune cells, surface-engineered immune cells, immunocytes' cell membranes, leukocyte-derived extracellular vesicles or exosomes, and artificial immune cells have been investigated and a few have been introduced into the market. These systems take advantage of the unique characteristics and functions of immune cells, including their presence in circulating blood and various tissues, complex crosstalk properties, high affinity to different self and foreign markers, unique potential of their on-demand navigation and activity, production of a variety of chemokines/cytokines, as well as being cytotoxic in particular conditions. Here, the latest progress in the development of engineered therapeutics and diagnostics inspired by immune cells to ameliorate cancer, inflammatory conditions, autoimmune diseases, neurodegenerative disorders, cardiovascular complications, and infectious diseases is reviewed, and finally, the perspective for their clinical application is delineated.
Identifiants
pubmed: 33898169
doi: 10.1002/advs.202002499
pii: ADVS2326
pmc: PMC8061401
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2002499Informations de copyright
© 2021 The Authors. Advanced Science published by Wiley‐VCH GmbH.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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