First case of Whipple's disease successfully treated with tigecycline.
Tropheryma whipplei treatment
Whipple’s disease
tigecycline
Journal
Germs
ISSN: 2248-2997
Titre abrégé: Germs
Pays: Romania
ID NLM: 101596099
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
07
01
2020
revised:
09
04
2020
accepted:
13
06
2020
entrez:
26
4
2021
pubmed:
27
4
2021
medline:
27
4
2021
Statut:
epublish
Résumé
Whipple's disease is a rare chronic infectious disease caused by We describe a case of a 42-year-old woman with a history of chronic diarrhea and weight loss evolving for at least the last 6 years. The diagnosis of Whipple's disease was confirmed by histopathological examination of duodenal biopsy samples with Periodic acid-Schiff positive macrophages and by polymerase chain reaction technique detecting the DNA of The intriguing thing with this case was not only the natural resistance to co-trimoxazole but that the infection was controlled empirically with long-lasting i.v. tigecycline since several failed attempts to discontinue i.v. treatment followed. This might be due to erratic absorption of oral drugs due to gut inflammation. To our knowledge, this is the first case of Whipple's disease successfully treated with long-lasting induction parenteral tigecycline followed by p.o. doxycycline along with hydroxychloroquine for one year and after by p.o. doxycycline alone.
Identifiants
pubmed: 33898347
doi: 10.18683/germs.2021.1246
pii: germs.2021.1246
pmc: PMC8057852
doi:
Types de publication
Case Reports
Langues
eng
Pagination
105-110Informations de copyright
GERMS.
Déclaration de conflit d'intérêts
Conflicts of interest: All authors – none to declare.
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