Antibacterial Composite Materials Based on the Combination of Polyhydroxyalkanoates With Selenium and Strontium Co-substituted Hydroxyapatite for Bone Regeneration.
antibacterial
composites
hydroxyapatite
polyhydroxyalkanoates
selenium
strontium
Journal
Frontiers in bioengineering and biotechnology
ISSN: 2296-4185
Titre abrégé: Front Bioeng Biotechnol
Pays: Switzerland
ID NLM: 101632513
Informations de publication
Date de publication:
2021
2021
Historique:
received:
28
12
2020
accepted:
04
03
2021
entrez:
26
4
2021
pubmed:
27
4
2021
medline:
27
4
2021
Statut:
epublish
Résumé
Due to the threat posed by the rapid growth in the resistance of microbial species to antibiotics, there is an urgent need to develop novel materials for biomedical applications capable of providing antibacterial properties without the use of such drugs. Bone healing represents one of the applications with the highest risk of postoperative infections, with potential serious complications in case of bacterial contaminations. Therefore, tissue engineering approaches aiming at the regeneration of bone tissue should be based on the use of materials possessing antibacterial properties alongside with biological and functional characteristics. In this study, we investigated the combination of polyhydroxyalkanoates (PHAs) with a novel antimicrobial hydroxyapatite (HA) containing selenium and strontium. Strontium was chosen for its well-known osteoinductive properties, while selenium is an emerging element investigated for its multi-functional activity as an antimicrobial and anticancer agent. Successful incorporation of such ions in the HA structure was obtained. Antibacterial activity against
Identifiants
pubmed: 33898403
doi: 10.3389/fbioe.2021.647007
pmc: PMC8059794
doi:
Types de publication
Journal Article
Langues
eng
Pagination
647007Informations de copyright
Copyright © 2021 Marcello, Maqbool, Nigmatullin, Cresswell, Jackson, Basnett, Knowles, Boccaccini and Roy.
Déclaration de conflit d'intérêts
MM is currently employed by company CAM Bioceramics B.V. MC and PJ are employed by Lucideon Ltd. During this research MM was however affiliated as a Ph.D. student at the University of Erlangen-Nuremberg, Germany and Lucideon Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Mater Sci Eng C Mater Biol Appl. 2013 Jul 1;33(5):2776-87
pubmed: 23623096
Colloids Surf B Biointerfaces. 2016 Apr 1;140:297-306
pubmed: 26764116
Regen Biomater. 2018 Aug;5(4):197-211
pubmed: 30094059
Ann Biomed Eng. 2015 Mar;43(3):515-28
pubmed: 25476163
Eng Life Sci. 2016 Oct 24;17(4):420-429
pubmed: 32624787
Biometals. 1998 Sep;11(3):223-7
pubmed: 9850565
Nanotechnol Sci Appl. 2014 Nov 07;7:97-104
pubmed: 25404853
Biomaterials. 2008 Apr;29(12):1750-61
pubmed: 18255139
J Tissue Eng. 2018 Jun 04;9:2041731418776819
pubmed: 29899969
Biomaterials. 2006 Jun;27(18):3413-31
pubmed: 16504284
J Biomed Mater Res A. 2013 Mar;101(3):853-61
pubmed: 22968925
J Microbiol Methods. 2001 Mar 1;44(2):121-9
pubmed: 11165341
Scientifica (Cairo). 2016;2016:9176273
pubmed: 27066293
Materials (Basel). 2019 Feb 14;12(4):
pubmed: 30769821
J Dent Res. 2011 Sep;90(9):1052-61
pubmed: 21248364
Biomaterials. 2005 Sep;26(27):5474-91
pubmed: 15860204
Nanoscale. 2019 Aug 8;11(31):14937-14951
pubmed: 31363721
Bioengineering (Basel). 2019 Nov 29;6(4):
pubmed: 31795345
J Tissue Eng Regen Med. 2018 Jun;12(6):1448-1468
pubmed: 29701908
Biomater Sci. 2019 Oct 1;7(10):3961-3983
pubmed: 31364613
Nanoscale Res Lett. 2015 Dec;10(1):989
pubmed: 26138453
Sci Rep. 2015 Dec 07;5:17884
pubmed: 26640089
J Mater Chem B. 2017;5(7):1430-1445
pubmed: 28944060
J Bone Miner Res. 2001 Aug;16(8):1556-63
pubmed: 11499879
Biomed Mater. 2009 Feb;4(1):015003
pubmed: 18981546
Biomed Mater. 2020 Jul 01;15(4):045024
pubmed: 32100724
J Biomed Mater Res A. 2004 Mar 1;68(3):513-21
pubmed: 14762931
Prog Biomater. 2012 Sep 26;1(1):2
pubmed: 29470743
J Biomed Mater Res B Appl Biomater. 2017 Jul;105(5):1285-1299
pubmed: 26991026
Biomed Mater Eng. 2014;24(2):1447-56
pubmed: 24642972
Bone. 2004 Sep;35(3):583-8
pubmed: 15336592
Mater Sci Eng C Mater Biol Appl. 2019 Nov;104:109895
pubmed: 31500047
J Orthop Surg Res. 2018 Feb 12;13(1):33
pubmed: 29433544
Biomaterials. 2000 Nov;21(21):2147-54
pubmed: 10985487
J Orthop Trauma. 2019 Apr;33(4):203-213
pubmed: 30633080
J Mater Chem B. 2019 Oct 16;7(40):6109-6124
pubmed: 31549696
J Biomed Mater Res. 2002 Dec 15;62(4):600-12
pubmed: 12221709
J Mater Chem B. 2016 Jan 21;4(3):409-421
pubmed: 32263206
J R Soc Interface. 2010 Feb 6;7(43):209-27
pubmed: 19864265
J Mater Sci Mater Med. 2018 Nov 30;29(12):179
pubmed: 30506294
Biomacromolecules. 2003 Jul-Aug;4(4):1092-7
pubmed: 12857097
RSC Adv. 2019 Aug 21;9(45):26252-26262
pubmed: 35531040
Materials (Basel). 2017 Mar 24;10(4):
pubmed: 28772697
Biomaterials. 2008 Jul;29(19):2858-68
pubmed: 18406457
Acta Naturae. 2019 Apr-Jun;11(2):4-16
pubmed: 31413875
Int J Nanomedicine. 2017 Mar 08;12:1841-1851
pubmed: 28331309
Extremophiles. 2015 Mar;19(2):515-24
pubmed: 25663452
Acta Biomater. 2018 Apr 15;71:225-234
pubmed: 29501818
Microbiol Res. 2016 Nov;192:271-282
pubmed: 27664746
Front Microbiol. 2016 Apr 26;7:571
pubmed: 27199909
Malays Orthop J. 2019 Jul;13(2):1-10
pubmed: 31467644
Interface Focus. 2012 Jun 6;2(3):378-86
pubmed: 23741613
Biomed Res Int. 2014;2014:178123
pubmed: 24949423
Biomaterials. 2007 Mar;28(7):1452-60
pubmed: 17140655