Anxiety disorders and asthma among adolescents in Uganda: role of early-life exposures.
Journal
ERJ open research
ISSN: 2312-0541
Titre abrégé: ERJ Open Res
Pays: England
ID NLM: 101671641
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
13
10
2020
accepted:
05
03
2021
entrez:
26
4
2021
pubmed:
27
4
2021
medline:
27
4
2021
Statut:
epublish
Résumé
The reasons for the positive association between anxiety disorders and asthma are unknown. We investigated the possible role of shared exposures in early life. We conducted a case-control study among adolescents (age 12-17 years) with and without asthma in urban Uganda, as part of a larger asthma case-control study. Anxiety disorders were diagnosed by psychiatric clinical officers. We focused on generalised anxiety disorder (GAD), panic disorder and social anxiety disorder. Asthma was doctor-diagnosed by study clinicians. We used questionnaires to collect data on early-life exposures. The data were analysed using multiple logistic regression. We enrolled 162 adolescents; 73 of them had asthma. Adolescents with asthma were more likely to have any of the three anxiety disorders studied (46.6%) than adolescents without asthma (21.4%) (adjusted OR (aOR) 2.68, 95% CI 1.30-5.53). The association was strong for GAD (aOR 4.49, 95% CI 1.48-13.56) and panic disorder (aOR 5.43, 95% CI 2.11-14.02), but not for social anxiety disorder. The early-life risk factors associated with anxiety disorders among adolescents were similar to asthma risk factors previously published, including urban residence at birth (aOR 3.42, 95% CI 1.29-9.09) and during most of the first 5 years of life (aOR 2.87, 95% CI 1.07-7.66), father's tertiary education (aOR 2.09, 95% CI 1.00-4.37), and adolescent's history of other allergy-related diseases (aOR 4.64, 95% CI 1.66-13.00). We confirm a positive association between anxiety disorders and asthma among adolescents in urban Uganda. The early-life risk factors associated with anxiety disorders among adolescents were similar to those for asthma in the same age group, suggesting shared underlying environmental exposures.
Identifiants
pubmed: 33898614
doi: 10.1183/23120541.00749-2020
pii: 00749-2020
pmc: PMC8053906
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Wellcome Trust
ID : 102512
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 095778
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L004623/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UP_1204/10
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 205069/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00027/5
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R010161/1
Pays : United Kingdom
Informations de copyright
Copyright ©The authors 2021. This version is distributed under the terms of the Creative Commons Attribution Licence 4.0.
Déclaration de conflit d'intérêts
Conflict of interest: H. Mpairwe has nothing to disclose. Conflict of interest: R.S. Mpango has nothing to disclose. Conflict of interest: W. Sembajjwe has nothing to disclose. Conflict of interest: E.L. Webb has nothing to disclose. Conflict of interest: A.M. Elliott has nothing to disclose. Conflict of interest: N. Pearce has nothing to disclose. Conflict of interest: E. Kinyanda has nothing to disclose.
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