Vertebral augmentation reduces the 12-month mortality and morbidity in patients with osteoporotic vertebral compression fractures.
Conservative treatment
Kyphoplasty
Osteoporosis
Spinal fractures
Vertebroplasty
Journal
European radiology
ISSN: 1432-1084
Titre abrégé: Eur Radiol
Pays: Germany
ID NLM: 9114774
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
22
01
2021
accepted:
02
04
2021
revised:
26
02
2021
pubmed:
27
4
2021
medline:
21
10
2021
entrez:
26
4
2021
Statut:
ppublish
Résumé
To investigate the 12-month all-cause mortality and morbidity in patients with osteoporotic vertebral compression fractures (OVCFs) undergoing vertebroplasty/balloon kyphoplasty (VP/BKP) versus non-surgical management (NSM). Following a Medline and EMBASE search for English language articles published from 2010 to 2019, 19 studies reporting on mortality and morbidity after VP/BKP in patients with OVCFs were selected. The 12-month timeline was set due to the largest amount of data availability at such time interval. Estimates for each study were reported as odds ratios (OR) along with 95% confidence intervals (CI) and p values. Fixed or random-effects meta-analyses were performed. All tests were based on a two-sided significance level of 0.05. Pooled OR across 5 studies favored VP/BKP over NSM in terms of 12-month all-cause mortality (OR: 0.81 [95% CI: 0.46-1.42]; p = .46). Pooled OR across 11 studies favored VP/BKP over NSM in terms of 12-month all-cause morbidity (OR: 0.64 [95% CI: 0.31-1.30]; p = .25). Sub-analysis of data dealing with 12-month infective morbidity from any origin confirmed the benefit of VP/BKP over NSM (OR: 0.23 [95% CI, 0.02-2.54]; p = .23). Compared to NSM, VP/BKP reduces the 12-month risk of all-cause mortality and morbidity by 19% and 36%, respectively. Moreover, VP/BKP reduces by 77% the 12-month risk of infection from any origin. • Compared to non-surgical management, vertebral augmentation reduces the 12-month risk of all-cause mortality by 19% and all-cause morbidity by 36%. • Vertebral augmentation reduces the 12-month risk of infection morbidity from any origin by 77%.
Identifiants
pubmed: 33899142
doi: 10.1007/s00330-021-07985-9
pii: 10.1007/s00330-021-07985-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8246-8255Informations de copyright
© 2021. European Society of Radiology.
Références
Chang M, Zhang C, Shi J et al (2021) Comparison between seven osteoporotic vertebral compression fractures treatments: a systematic review and network meta-analysis. World Neurosurg 145:462–470.e1
pubmed: 32891841
Meyblum L, Premat K, Elhorany M et al (2020) Safety of vertebral augmentation with cranio-caudal expansion implants in vertebral compression fractures with posterior wall protrusion. Eur Radiol 30(10):5641–5649
pubmed: 32367420
Clark W, Bird P, Gonski P et al (2016) Safety and efficacy of vertebroplasty for acute painful osteoporotic fractures (VAPOUR): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet 388(10052):1408–1416
pubmed: 27544377
pmcid: 27544377
Yang EZ, Xu JG, Huang GZ et al (2016) Percutaneous vertebroplasty versus conservative treatment in aged patients with acute osteoporotic vertebral compression fractures: a prospective randomized controlled clinical study. Spine (Phila Pa 1976) 41(8):653–660
Hopkins TJ, Eggington S, Quinn M, Nichols-Ricker CI (2020) Cost-effectiveness of balloon kyphoplasty and vertebroplasty versus conservative medical management in the USA. Osteoporos Int 31(12):2461–2471
pubmed: 32656632
pmcid: 7661420
Buchbinder R, Osborne RH, Ebeling PR et al (2009) A randomized trial of vertebroplasty for painful osteoporotic vertebral fractures. N Engl J Med 361(6):557–568
pubmed: 19657121
pmcid: 19657121
Kallmes DF, Comstock BA, Heagerty PJ et al (2009) A randomized trial of vertebroplasty for osteoporotic spinal fractures. N Engl J Med 361(6):569–579
pubmed: 19657122
pmcid: 19657122
Ebeling PR, Akesson K, Bauer DC et al (2019) The efficacy and safety of vertebral augmentation: a second ASBMR task force report. J Bone Miner Res 34(1):3–21
pubmed: 30677181
Degnan AJ, Hemingway J, Hughes DR (2017) Medicare utilization of vertebral augmentation 2001 to 2014: effects of randomized clinical trials and guidelines on vertebroplasty and kyphoplasty. J Am Coll Radiol 14(8):1001–1006
pubmed: 28778222
Johnell O, Kanis JA (2006) An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 17(12):1726–1733
pubmed: 16983459
Hinde K, Maingard J, Hirsch JA, Phan K, Asadi H, Chandra RV (2020) Mortality outcomes of vertebral augmentation (vertebroplasty and/or balloon kyphoplasty) for osteoporotic vertebral compression fractures: a systematic review and meta-analysis. Radiology 295(1):96–103
pubmed: 32068503
Burge R, Puleo E, Gehlbach S, Worley D, Klar J (2002) Inpatient hospital and post-acute care for vertebral fractures in women. Value Health 5(4):301–311
pubmed: 12102693
Gehlbach SH, Burge RT, Puleo E, Klar J (2003) Hospital care of osteoporosis-related vertebral fractures. Osteoporos Int 14(1):53–60
pubmed: 12577185
Edidin AA, Ong KL, Lau E, Kurtz SM (2015) Morbidity and mortality after vertebral fractures: comparison of vertebral augmentation and nonoperative management in the medicare population. Spine (Phila Pa 1976) 40(15):1228–1241
Ong KL, Beall DP, Frohbergh M, Lau E, Hirsch JA (2018) Were VCF patients at higher risk of mortality following the 2009 publication of the vertebroplasty “sham” trials? Osteoporos Int 29(2):375–383
pubmed: 29063215
OCEBM Levels of Evidence — Centre for Evidence-Based Medicine (CEBM), University of Oxford [Internet]. [cited 2020 Oct 14]. Available from: https://www.cebm.ox.ac.uk/resources/levels-of-evidence/ocebm-levels-of-evidence
Klezl Z, Bhangoo N, Phillips J, Swamy G, Calthorpe D, Bommireddy R (2012) Social implications of balloon kyphoplasty: prospective study from a single UK centre. Eur Spine J 21(9):1880–1886
pubmed: 22492240
pmcid: 3459116
Kim YC, Bok DH, Chang HG et al (2016) Increased sagittal vertical axis is associated with less effective control of acute pain following vertebroplasty. Bone Joint Res 5(11):544–551
pubmed: 27831489
pmcid: 5131091
Farrokhi MR, Alibai E, Maghami Z (2011) Randomized controlled trial of percutaneous vertebroplasty versus optimal medical management for the relief of pain and disability in acute osteoporotic vertebral compression fractures. J Neurosurg Spine 14(5):561–569
pubmed: 21375382
pmcid: 21375382
Wang HK, Lu K, Liang CL et al (2010) Comparing clinical outcomes following percutaneous vertebroplasty with conservative therapy for acute osteoporotic vertebral compression fractures. Pain Med 11(11):1659–1665
pubmed: 21044255
Klazen CAH, Lohle PNM, de Vries J et al (2010) Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial. Lancet 376(9746):1085–1092
pubmed: 20701962
pmcid: 20701962
Balkarli H, Kilic M, Balkarli A, Erdogan M (2016) An evaluation of the functional and radiological results of percutaneous vertebroplasty versus conservative treatment for acute symptomatic osteoporotic spinal fractures. Injury 47(4):865–871
pubmed: 26922648
McDonald RJ, Achenbach SJ, Atkinson EJ et al (2011) Mortality in the vertebroplasty population. AJNR Am J Neuroradiol 32(10):1818–1823
pubmed: 21998109
pmcid: 3217093
Ishiguro S, Kasai Y, Sudo A, Iida K, Uchida A (2010) Percutaneous vertebroplasty for osteoporotic compression fractures using calcium phosphate cement. J Orthop Surg 18(3):346–351
Chen D, An ZQ, Song S, Tang JF, Qin H (2014) Percutaneous vertebroplasty compared with conservative treatment in patients with chronic painful osteoporotic spinal fractures. J Clin Neurosci 21(3):473–477
pubmed: 24315046
Lee HM, Park SY, Lee SH, Suh SW, Hong JY (2012) Comparative analysis of clinical outcomes in patients with osteoporotic vertebral compression fractures (OVCFs): conservative treatment versus balloon kyphoplasty. Spine J 12(11):998–1005
pubmed: 23026068
Movrin I (2012) Adjacent level fracture after osteoporotic vertebral compression fracture: a nonrandomized prospective study comparing balloon kyphoplasty with conservative therapy. Wien Klin Wochenschr 124(9–10):304–311
pubmed: 22527828
Oh Y, Lee B, Lee S, Kim J, Park J (2019) Percutaneous vertebroplasty versus conservative treatment using a transdermal fentanyl patch for osteoporotic vertebral compression fractures. J Korean Neurosurg Soc 62(5):594–602
pubmed: 31484234
pmcid: 6732346
Tang H, Zhao J, Hao C (2011) Osteoporotic vertebral compression fractures: surgery versus non-operative management. J Int Med Res 39(4):1438–1447
pubmed: 21986146
Boonen S, Van Meirhaeghe J, Bastian L et al (2011) Balloon kyphoplasty for the treatment of acute vertebral compression fractures: 2-year results from a randomized trial. J Bone Miner Res 26(7):1627–1637
pubmed: 21337428
pmcid: 21337428
Martikos K, Greggi T, Faldini C et al (2018) Osteoporotic thoracolumbar compression fractures: long-term retrospective comparison between vertebroplasty and conservative treatment. Eur Spine J 27(Suppl 2):244–247
pubmed: 29675674
Blasco J, Martinez-Ferrer A, Macho J et al (2012) Effect of vertebroplasty on pain relief, quality of life, and the incidence of new vertebral fractures: a 12-month randomized follow-up, controlled trial. J Bone Miner Res 27(5):1159–1166
pubmed: 22513649
pmcid: 22513649
Ee GWW, Lei J, Guo CM et al Comparison of clinical outcomes and radiographic measurements in 4 different treatment modalities for osteoporotic compression fractures. J Spinal Disord Tech 28(6):E328–E335
Venmans A, Klazen CA, van Rooij WJ, de Vries J, Mali WP, Lohle PN (2011) Postprocedural CT for perivertebral cement leakage in percutaneous vertebroplasty is not necessary—results from VERTOS II. Neuroradiology 53(1):19–22
Voormolen MHJ, Mali WPTM, Lohle PNM et al (2007) Percutaneous vertebroplasty compared with optimal pain medication treatment: short-term clinical outcome of patients with subacute or chronic painful osteoporotic vertebral compression fractures. The VERTOS study. AJNR Am J Neuroradiol 28(3):555–560
pubmed: 17353335
pmcid: 7977842
Luetmer MT, Kallmes DF (2011) Have referral patterns for vertebroplasty changed since publication of the placebo-controlled trials? AJNR Am J Neuroradiol 32(4):647–648
pubmed: 21349971
pmcid: 7965867
Hirsch JA, Chandra RV, Carter NS, Beall D, Frohbergh M, Ong K (2020) Number needed to treat with vertebral augmentation to save a life. AJNR Am J Neuroradiol 41(1):178–182
pubmed: 31857326
pmcid: 6975314
Knight J, Nigam Y, Jones A (2009) Effects of bedrest 1: cardiovascular, respiratory and haematological systems. Nurs Times 105(21):16–20
pubmed: 19548502
Knight J, Nigam Y, Jones A (2009) Effects of bedrest 2: gastrointestinal, endocrine, renal, reproductive and nervous systems. Nurs Times 105(22):24–27
pubmed: 19579399
Adogwa O, Elsamadicy AA, Fialkoff J, Cheng J, Karikari IO, Bagley C (2017) Early ambulation decreases length of hospital stay, perioperative complications and improves functional outcomes in elderly patients undergoing surgery for correction of adult degenerative scoliosis. Spine (Phila Pa 1976) 42(18):1420–1425
MacCallum KP, Kalata S, Darcy D et al (2020) Prolonged use of spinal precautions is associated with increased morbidity in the trauma patient. Injury 51(2):317–321
pubmed: 31917010
Rousing R, Hansen KL, Andersen MO, Jespersen SM, Thomsen K, Lauritsen JM (2010) Twelve-months follow-up in forty-nine patients with acute/semiacute osteoporotic vertebral fractures treated conservatively or with percutaneous vertebroplasty: a clinical randomized study. Spine (Phila Pa 1976) 35(5):478–482
Lou S, Shi X, Zhang X, Lyu H, Li Z, Wang Y (2019) Percutaneous vertebroplasty versus non-operative treatment for osteoporotic vertebral compression fractures: a meta-analysis of randomized controlled trials. Osteoporos Int 30(12):2369–2380
pubmed: 31375875
Kelekis A, Filippiadis DK, Vergadis C et al (2014) Comparative prospective study of load distribution projection among patients with vertebral fractures treated with percutaneous vertebroplasty and a control group of healthy volunteers. Cardiovasc Intervent Radiol 37(1):186–192
pubmed: 23580118
Lange A, Kasperk C, Alvares L, Sauermann S, Braun S (2014) Survival and cost comparison of kyphoplasty and percutaneous vertebroplasty using German claims data. Spine (Phila Pa 1976) 39(4):318–326
Zhang H, Xu C, Zhang T, Gao Z, Zhang T (2017) Does percutaneous vertebroplasty or balloon kyphoplasty for osteoporotic vertebral compression fractures increase the incidence of new vertebral fractures? A Meta-Analysis. Pain Physician 20(1):E13–E28
pubmed: 28072794
pmcid: 28072794
Li HM, Zhang RJ, Gao H et al (2018) New vertebral fractures after osteoporotic vertebral compression fracture between balloon kyphoplasty and nonsurgical treatment PRISMA. Medicine (Baltimore) 97(40):e12666
Chen Z, Chen Z, Wu Y et al (2019) Risk factors of secondary vertebral compression fracture after percutaneous vertebroplasty or kyphoplasty: a retrospective study of 650 patients. Med Sci Monit 2019(25):9255–9261
Cao J, Kong L, Meng F, Zhang Y, Shen Y (2016) Risk factors for new vertebral compression fractures after vertebroplasty: a meta-analysis. ANZ J Surg 86(7–8):549–554
pubmed: 26749512
Chen YC, Lin WC (2016) Can anti-osteoporotic therapy reduce adjacent fracture in magnetic resonance imaging-proven acute osteoporotic vertebral fractures? BMC Musculoskelet Disord 17:151
pubmed: 27052323
pmcid: 4823884
Chen YC, Lin WC (2017) Poor 1st-year adherence to anti-osteoporotic therapy increases the risk of mortality in patients with magnetic resonance imaging-proven acute osteoporotic vertebral fractures. Patient Prefer Adherence 11:839–843
pubmed: 28490865
pmcid: 5414717