Human NK cells, their receptors and function.
Adaptive NK cells
Human NK cells
Inhibitory checkpoints
NK cell receptors
TLR
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
revised:
20
03
2021
received:
19
01
2021
accepted:
08
04
2021
pubmed:
27
4
2021
medline:
1
10
2021
entrez:
26
4
2021
Statut:
ppublish
Résumé
NK cells are cytotoxic components of innate lymphoid cells (ILC) that provide a first line of defense against viral infections and contribute to control tumor growth and metastasis. Their function is finely regulated by an array of HLA-specific and non-HLA-specific inhibitory and activating receptors which allow to discriminate between healthy and altered cells. Human NK cells gained a major attention in recent years because of the important progresses in understanding their biology and of some promising data in tumor therapy. In this review, we will outline well-established issues of human NK cells and discuss some of the open questions, debates, and recent advances regarding their origin, differentiation, and tissue distribution. Newly defined NK cell specializations, including the impact of inhibitory checkpoints on their function, their crosstalk with other cell types, and the remarkable adaptive features acquired in response to certain virus infections will also be discussed.
Identifiants
pubmed: 33899224
doi: 10.1002/eji.202049028
pmc: PMC9292411
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1566-1579Informations de copyright
© 2021 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.
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