Active Case Finding of Current Bornavirus Infections in Human Encephalitis Cases of Unknown Etiology, Germany, 2018-2020.
BoDV-1
Germany
VSBV-1
active case finding
bornavirus
bornavirus disease virus 1
case definition
epidemiology
etiology
human encephalitis
infections
meningitis/encephalitis
serologic analysis
variegated squirrel bornavirus 1
viruses
zoonoses
Journal
Emerging infectious diseases
ISSN: 1080-6059
Titre abrégé: Emerg Infect Dis
Pays: United States
ID NLM: 9508155
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
entrez:
26
4
2021
pubmed:
27
4
2021
medline:
6
7
2021
Statut:
ppublish
Résumé
Human bornavirus encephalitis is a severe and often fatal infection caused by variegated squirrel bornavirus 1 (VSBV-1) and Borna disease virus 1 (BoDV-1). We conducted a prospective study of bornavirus etiology of encephalitis cases in Germany during 2018-2020 by using a serologic testing scheme applied along proposed graded case definitions for VSBV-1, BoDV-1, and unspecified bornavirus encephalitis. Of 103 encephalitis cases of unknown etiology, 4 bornavirus infections were detected serologically. One chronic case was caused by VSBV-1 after occupational-related contact of a person with exotic squirrels, and 3 acute cases were caused by BoDV-1 in virus-endemic areas. All 4 case-patients died. Bornavirus etiology could be confirmed by molecular methods. Serologic testing for these cases was virus specific, discriminatory, and a practical diagnostic option for living patients if no brain tissue samples are available. This testing should be guided by clinical and epidemiologic suspicions, such as residence in virus-endemic areas and animal exposure.
Identifiants
pubmed: 33900167
doi: 10.3201/eid2705.204490
pmc: PMC8084505
doi:
Substances chimiques
RNA, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1371-1379Commentaires et corrections
Type : CommentIn
Références
Lancet Infect Dis. 2020 Apr;20(4):467-477
pubmed: 31924550
PLoS Pathog. 2019 Aug 1;15(8):e1007873
pubmed: 31369648
Mol Psychiatry. 2012 May;17(5):486-93
pubmed: 22290118
Emerg Microbes Infect. 2017 Jun 21;6(6):e52
pubmed: 28634359
Emerg Infect Dis. 2018 Jun;24(6):978-987
pubmed: 29774846
N Engl J Med. 2015 Jul 9;373(2):154-62
pubmed: 26154788
Emerg Infect Dis. 2019 Jun;25(6):1058-1065
pubmed: 31107210
Euro Surveill. 2019 Feb;24(8):
pubmed: 30808439
Transbound Emerg Dis. 2020 Mar 29;:
pubmed: 32223069
N Engl J Med. 2018 Oct 4;379(14):1377-1379
pubmed: 30281984
Sci Rep. 2019 Dec 27;9(1):20154
pubmed: 31882942
Biol Psychiatry. 2002 Jun 15;51(12):979-87
pubmed: 12062882
Acta Neuropathol. 2019 Jun;137(6):1017-1019
pubmed: 30953131
Acta Neuropathol. 2019 Oct;138(4):653-665
pubmed: 31346692
Emerg Infect Dis. 2017 Mar;23(3):477-481
pubmed: 28221112
J Vet Diagn Invest. 2014 Nov;26(6):769-77
pubmed: 25135010
Clin Infect Dis. 2013 Oct;57(8):1114-28
pubmed: 23861361
Arch Virol. 2017 Sep;162(9):2747-2754
pubmed: 28593419
N Engl J Med. 2018 Oct 4;379(14):1375-1377
pubmed: 30281979
PLoS One. 2015 Aug 27;10(8):e0137018
pubmed: 26313904
J Gen Virol. 2005 Feb;86(Pt 2):385-398
pubmed: 15659758
PLoS One. 2014 Apr 03;9(4):e93659
pubmed: 24699636
Rev Med Virol. 2007 May-Jun;17(3):181-203
pubmed: 17342788