Outcomes of curative-intent radiotherapy in non-small cell lung cancer (NSCLC) patients with chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD).


Journal

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
ISSN: 1879-0887
Titre abrégé: Radiother Oncol
Pays: Ireland
ID NLM: 8407192

Informations de publication

Date de publication:
07 2021
Historique:
received: 30 07 2020
revised: 29 03 2021
accepted: 16 04 2021
pubmed: 27 4 2021
medline: 28 7 2021
entrez: 26 4 2021
Statut: ppublish

Résumé

Outcomes of non-small cell lung cancer (NSCLC) patients with chronic obstructive pulmonary disease (COPD n = 587) and interstitial lung disease (ILD n = 34) treated with curative-intent radiotherapy were retrospectively investigated. Presence of ILD but not decreased forced expiratory volume in 1-second correlated with poor overall survival. Increased breathlessness and oxygen requirements after radiotherapy were observed in severe/very severe COPD and ILD.

Identifiants

pubmed: 33901563
pii: S0167-8140(21)06207-1
doi: 10.1016/j.radonc.2021.04.014
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

78-81

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest C. Faivre-Finn has declared research grants from AstraZeneca, MSD and Elekta and sits on the advisory boards of AstraZeneca and Pfizer. D. Woolf has declared travel grants, consultancy and speaker fees from AstraZeneca and travel grants from Roche. None of the other co-authors have any relevant conflicts of interest.

Auteurs

Celion Tang (C)

Division of Medical Education, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.

Hitesh Mistry (H)

Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.

Neil Bayman (N)

Department Clinical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom.

Clara Chan (C)

Department Clinical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom.

David Cobben (D)

Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom; Department Clinical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom.

Corinne Faivre-Finn (C)

Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom; Department Clinical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom.

Margaret Harris (M)

Department Clinical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom.

Jason Kennedy (J)

Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.

Laura Pemberton (L)

Department Clinical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom.

Gareth Price (G)

Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom; Department Clinical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom.

Hamid Sheikh (H)

Department Clinical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom.

David Woolf (D)

Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom; Department Clinical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom.

Joanna Coote (J)

Department Clinical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom.

Ahmed Salem (A)

Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom; Department Clinical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom. Electronic address: ahmed.salem@manchester.ac.uk.

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