Prolonged and severe SARS-CoV-2 infection in patients under B-cell-depleting drug successfully treated: A tailored approach.
Anti-CD20 therapy
B-cell depletion
Prolonged infection
SARS-CoV-2 infection
Journal
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
ISSN: 1878-3511
Titre abrégé: Int J Infect Dis
Pays: Canada
ID NLM: 9610933
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
18
03
2021
revised:
16
04
2021
accepted:
21
04
2021
pubmed:
27
4
2021
medline:
3
7
2021
entrez:
26
4
2021
Statut:
ppublish
Résumé
Prolonged B-cell depletion due to anti-CD20 monoclonal antibody (mAbs) therapy impairs the adaptive immune response, causing severe manifestations during COronaVIrus Disease-2019 (COVID-19). The cases of two patients under anti-CD20 therapy who experienced prolonged and severe COVID-19 successfully treated with mAbs against Severe Acute Respiratory Syndrome-CoV-2 spike proteins are reported.
Identifiants
pubmed: 33901654
pii: S1201-9712(21)00380-5
doi: 10.1016/j.ijid.2021.04.068
pmc: PMC8065233
pii:
doi:
Substances chimiques
Antibodies, Monoclonal
0
Antigens, CD20
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
247-250Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors report no declarations of interest.
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