Antioxidant and anticoagulant effects of phenylpropanoid glycosides isolated from broomrapes (Orobanche caryophyllacea, Phelipanche arenaria, and P. ramosa).
Adult
Anticoagulants
/ pharmacology
Antioxidants
/ pharmacology
Biphenyl Compounds
/ chemistry
Catechols
/ chemistry
Chromans
/ pharmacology
Cistanche
Female
Free Radical Scavengers
/ pharmacology
Glycosides
/ pharmacology
Hemostasis
/ drug effects
Humans
Male
Orobanchaceae
/ chemistry
Orobanche
/ chemistry
Picrates
/ chemistry
Plant Extracts
/ pharmacology
Propionates
/ chemistry
Protective Agents
/ pharmacology
Spectrophotometry, Ultraviolet
Structure-Activity Relationship
Broomrape
Hemostasis
Oxidative stress
Phenylpropanoid glycosides
Plasma
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
04
03
2021
revised:
03
04
2021
accepted:
12
04
2021
pubmed:
27
4
2021
medline:
27
7
2021
entrez:
26
4
2021
Statut:
ppublish
Résumé
Holoparasitic plants of the Orobanchaceae, including Cistanche, Orobanche, and Phelipanche spp, are known for their richness of phenylpropanoid glycosides (PPGs). Many PPG compounds have been found to possess a wide spectrum of activities, such as antimicrobial, anti-inflammatory, antioxidant, and memory-enhancing. To better explore the bioactivity potential of European broomrapes (O. caryophyllacea - OC, P. arenaria - PA, P. ramosa - PR) and ten single isolated phenylpropanoid constituents, we investigated their antiradical action, protective effect against oxidation in plasma in vitro system, and influence on coagulation parameters. The tested extracts showed a scavenging activity of 50-70% of Trolox's power. The OC extract, rich in acteoside, had over 20% better antiradical potential than PR extract which was the only one containing PPGs lacking a B-ring catechol moiety in the acyl unit. Moreover, it was found that only eight tested PPGs demonstrated antioxidant potential in human plasma treated with H
Identifiants
pubmed: 33901871
pii: S0753-3322(21)00403-0
doi: 10.1016/j.biopha.2021.111618
pii:
doi:
Substances chimiques
Anticoagulants
0
Antioxidants
0
Biphenyl Compounds
0
Catechols
0
Chromans
0
Free Radical Scavengers
0
Glycosides
0
Picrates
0
Plant Extracts
0
Propionates
0
Protective Agents
0
1,1-diphenyl-2-picrylhydrazyl
DFD3H4VGDH
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
S18UL9710X
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
111618Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Masson SAS.. All rights reserved.