Association between pesticide and polychlorinated biphenyl exposure during pregnancy and autism spectrum disorder among children: a meta-analysis.
Autism
Autism spectrum disorders
Meta-analysis
Pesticides
Polychlorinated biphenyls
Journal
Clinical and experimental pediatrics
ISSN: 2713-4148
Titre abrégé: Clin Exp Pediatr
Pays: Korea (South)
ID NLM: 101761234
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
10
05
2020
accepted:
25
07
2020
pubmed:
28
4
2021
medline:
28
4
2021
entrez:
27
4
2021
Statut:
ppublish
Résumé
The effect of exposure to environmental factors on autism spectrum disorders (ASD), especially during pregnancy, is unclear. This meta-analysis investigated the association between exposure to pesticides and polychlorinated biphenyls (PCBs) during pregnancy and ASD risk among children. We searched Scopus, PubMed, Web of Science, and ProQuest for articles published through September 2019. Random-effects models were used to examine the association among studies using pooled odds ratios (ORs) and their 95% confidence intervals (CI). I2 tests were used to measure interstudy heterogeneity. The pooled OR indicated a significant association between PCB and pesticide exposure during pregnancy and ASD risk among children (OR, 1.80; 95% CI, 1.26-2.34; and OR, 1.20; 95% CI, 1.02-1.39), respectively. Findings of the present study indicate that exposure to pesticides and PCBs during pregnancy may affect the risk of ASD among children.
Sections du résumé
BACKGROUND
BACKGROUND
The effect of exposure to environmental factors on autism spectrum disorders (ASD), especially during pregnancy, is unclear.
PURPOSE
OBJECTIVE
This meta-analysis investigated the association between exposure to pesticides and polychlorinated biphenyls (PCBs) during pregnancy and ASD risk among children.
METHODS
METHODS
We searched Scopus, PubMed, Web of Science, and ProQuest for articles published through September 2019. Random-effects models were used to examine the association among studies using pooled odds ratios (ORs) and their 95% confidence intervals (CI). I2 tests were used to measure interstudy heterogeneity.
RESULTS
RESULTS
The pooled OR indicated a significant association between PCB and pesticide exposure during pregnancy and ASD risk among children (OR, 1.80; 95% CI, 1.26-2.34; and OR, 1.20; 95% CI, 1.02-1.39), respectively.
CONCLUSION
CONCLUSIONS
Findings of the present study indicate that exposure to pesticides and PCBs during pregnancy may affect the risk of ASD among children.
Identifiants
pubmed: 33902270
pii: cep.2020.00864
doi: 10.3345/cep.2020.00864
pmc: PMC8181020
doi:
Types de publication
Journal Article
Langues
eng
Pagination
286-292Références
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