Engineered Conotoxin Differentially Blocks and Discriminates Rat and Human α7 Nicotinic Acetylcholine Receptors.

Amino Acid Sequence Animals Binding Sites Conotoxins / chemical synthesis Humans Inhibitory Concentration 50 Isomerism Ligands Molecular Dynamics Simulation Mutagenesis Oocytes / metabolism Rats Sequence Alignment Species Specificity Xenopus / metabolism alpha7 Nicotinic Acetylcholine Receptor / antagonists & inhibitors

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
13 05 2021
Historique:
pubmed: 28 4 2021
medline: 17 6 2021
entrez: 27 4 2021
Statut: ppublish

Résumé

The α7 nicotinic acetylcholine receptor (nAChR) is present in the central nervous system and plays an important role in cognitive function and memory. α-Conotoxin LvIB, identified from genomic DNA of

Identifiants

DOI: 10.1021/acs.jmedchem.0c02079 PMID: 33902275
pubmed: 33902275
doi: 10.1021/acs.jmedchem.0c02079
doi:

Substances chimiques

Conotoxins 0
Ligands 0
alpha7 Nicotinic Acetylcholine Receptor 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

5620-5631

Auteurs

Shuai Wang (S)

Key Laboratory of Tropical Biological Resources of Ministry of Education, Key Laboratory for Marine Drugs of Haikou, School of Life and Pharmaceutical Sciences, Hainan University, Haikou 570228, China.

Xiaopeng Zhu (X)

Key Laboratory of Tropical Biological Resources of Ministry of Education, Key Laboratory for Marine Drugs of Haikou, School of Life and Pharmaceutical Sciences, Hainan University, Haikou 570228, China.
Medical School, Guangxi University, Nanning 530004, China.
ORCID: 0000-0001-8830-4954

Manqi Zhangsun (M)

Key Laboratory of Tropical Biological Resources of Ministry of Education, Key Laboratory for Marine Drugs of Haikou, School of Life and Pharmaceutical Sciences, Hainan University, Haikou 570228, China.

Yong Wu (Y)

Medical School, Guangxi University, Nanning 530004, China.

Jinpeng Yu (J)

Medical School, Guangxi University, Nanning 530004, China.

Peta J Harvey (PJ)

Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland 4072, Australia.
ORCID: 0000-0003-4735-6242

Quentin Kaas (Q)

Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland 4072, Australia.
ORCID: 0000-0001-9988-6152

Dongting Zhangsun (D)

Key Laboratory of Tropical Biological Resources of Ministry of Education, Key Laboratory for Marine Drugs of Haikou, School of Life and Pharmaceutical Sciences, Hainan University, Haikou 570228, China.
Medical School, Guangxi University, Nanning 530004, China.

David J Craik (DJ)

Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland 4072, Australia.
ORCID: 0000-0003-0007-6796

Sulan Luo (S)

Key Laboratory of Tropical Biological Resources of Ministry of Education, Key Laboratory for Marine Drugs of Haikou, School of Life and Pharmaceutical Sciences, Hainan University, Haikou 570228, China.
Medical School, Guangxi University, Nanning 530004, China.
ORCID: 0000-0002-3568-5797

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › Engineered Conotoxin Differentially Blocks and...
questionsmedicales.fr › Eucaryotes › Animaux › Engineered Conotoxin Differentially Blocks and...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Engineered Conotoxin Differentially Blocks and...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Venins › Venins de mollusque › Conotoxines › Engineered Conotoxin Differentially Blocks and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Engineered Conotoxin Differentially Blocks and...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Concentration inhibitrice 50 › Engineered Conotoxin Differentially Blocks and...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes de chimie organique › Isomérie › Engineered Conotoxin Differentially Blocks and...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Engineered Conotoxin Differentially Blocks and...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › Engineered Conotoxin Differentially Blocks and...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Engineered Conotoxin Differentially Blocks and...
questionsmedicales.fr › Cellules › Cellules germinales › Ovocytes › Engineered Conotoxin Differentially Blocks and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Engineered Conotoxin Differentially Blocks and...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Alignement de séquences › Engineered Conotoxin Differentially Blocks and...
questionsmedicales.fr › Phénomènes biologiques › Spécificité d'espèce › Engineered Conotoxin Differentially Blocks and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Amphibiens › Anura › Pipidae › Xenopus › Engineered Conotoxin Differentially Blocks and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs cholinergiques › Récepteurs nicotiniques › Récepteur nicotinique de l'acétylcholine alpha7 › Engineered Conotoxin Differentially Blocks and...