Is immunotherapy in the future of therapeutic management of sarcomas?
Anti-cancer vaccine
CAR-T therapy
Immunotherapy
Osteosarcoma
Soft tissue sarcoma
Journal
Journal of translational medicine
ISSN: 1479-5876
Titre abrégé: J Transl Med
Pays: England
ID NLM: 101190741
Informations de publication
Date de publication:
26 04 2021
26 04 2021
Historique:
received:
25
01
2021
accepted:
12
04
2021
entrez:
27
4
2021
pubmed:
28
4
2021
medline:
15
5
2021
Statut:
epublish
Résumé
Sarcomas are rare, ubiquitous and heterogeneous tumors usually treated with surgery, chemotherapy, target therapy, and radiotherapy. However, 25-50% of patients experience local relapses and/or distant metastases after chemotherapy with an overall survival about 12-18 months. Recently, immuno-therapy has revolutionized the cancer treatments with initial indications for non-small cell lung cancer (NSCLC) and melanoma (immune-checkpoint inhibitors).Here, we provide a narrative review on the topic as well as a critical description of the currently available trials on immunotherapy treatments in patients with sarcoma. Given the promising results obtained with anti-PD-1 monoclonal antibodies (pembrolizumab and nivolumab) and CAR-T cells, we strongly believe that these new immunotherapeutic approaches, along with an innovative characterization of tumor genetics, will provide an exciting opportunity to ameliorate the therapeutic management of sarcomas.
Identifiants
pubmed: 33902630
doi: 10.1186/s12967-021-02829-y
pii: 10.1186/s12967-021-02829-y
pmc: PMC8077947
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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