Towards more Sustainable Peptide- based Antibiotics: Stable in Human Blood, Enzymatically Hydrolyzed in Wastewater?

Anti-Bacterial Agents Drug Resistance, Microbial Humans Peptides Wastewater Water Purification

Journal

Chimia
ISSN: 0009-4293
Titre abrégé: Chimia (Aarau)
Pays: Switzerland
ID NLM: 0373152

Informations de publication

Date de publication:
28 Apr 2021
Historique:
entrez: 27 4 2021
pubmed: 28 4 2021
medline: 29 4 2021
Statut: ppublish

Résumé

The emergence and spread of antibiotic resistance is a major societal challenge and new antibiotics are needed to successfully fight bacterial infections. Because the release of antibiotics into wastewater and downstream environments is expected to contribute to the problem of antibiotic resistance, it would be beneficial to consider the environmental fate of antibiotics in the development of novel antibiotics. In this article, we discuss the possibility of designing peptide-based antibiotics that are stable during treatment (

Identifiants

DOI: 10.2533/chimia.2021.267 PMID: 33902793
pubmed: 33902793
doi: 10.2533/chimia.2021.267
doi:

Substances chimiques

Anti-Bacterial Agents 0
Peptides 0
Waste Water 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

267-271

Auteurs

Michael T Zumstein (MT)

Department of Environmental Geosciences, Centre for Microbiology and Environmental Systems Science, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria; Environmental Microbiology Department, Swiss Federal Institute of Aquatic Science and Technology (Eawag), Überlandstrasse 133, CH-8600 Dübendorf, Switzerland; Environmental Chemistry Department, Swiss Federal Institute of Aquatic Science and Technology (Eawag), Überland- strasse 133, CH-8600 Dübendorf, Switzerland;, Email: michael.zumstein@univie.ac.at.

Kathrin Fenner (K)

Environmental Chemistry Department, Swiss Federal Institute of Aquatic Science and Technology (Eawag), Überland- strasse 133, CH-8600 Dübendorf, Switzerland; Department of Chemistry, University of Zurich, CH-8057 Zurich, Switzerland.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Towards more Sustainable Peptide- based...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Towards more Sustainable Peptide- based...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Towards more Sustainable Peptide- based...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Towards more Sustainable Peptide- based...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Déchets › Eaux usées › Towards more Sustainable Peptide- based...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Amélioration du niveau sanitaire › Génie sanitaire › Gestion des déchets › Purification de l'eau › Towards more Sustainable Peptide- based...