The tumour immune microenvironment in oesophageal cancer.
Journal
British journal of cancer
ISSN: 1532-1827
Titre abrégé: Br J Cancer
Pays: England
ID NLM: 0370635
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
26
07
2020
accepted:
17
02
2021
revised:
16
01
2021
pubmed:
28
4
2021
medline:
16
12
2021
entrez:
27
4
2021
Statut:
ppublish
Résumé
Oesophageal cancer (OC) is an inflammation-associated malignancy linked to gastro-oesophageal reflux disease, obesity and tobacco use. Knowledge of the microenvironment of oesophageal tumours is relevant to our understanding of the development of OC and its biology, and has major implications for understanding the response to standard therapies and immunotherapies, as well as for uncovering novel targets. In this context, we discuss what is known about the TME in OC from tumour initiation to development and progression, and how this is relevant to therapy sensitivity and resistance in the two major types of OC. We provide an immunological characterisation of the OC TME and discuss its prognostic implications with specific comparison with the Immunoscore and immune-hot, -cold, altered-immunosuppressed and -altered-excluded models. Targeted therapeutics for the TME under pre-clinical and clinical investigation in OCs are also summarised. A deeper understanding of the TME will enable the development of combination approaches to concurrently target the tumour cells and TME delivering precision medicine to OC patients.
Identifiants
pubmed: 33903730
doi: 10.1038/s41416-021-01331-y
pii: 10.1038/s41416-021-01331-y
pmc: PMC8368180
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
479-494Informations de copyright
© 2021. The Author(s), under exclusive licence to Cancer Research UK.
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