The Feasibility of Magnetic Resonance Imaging in a Non-Selective Comprehensive Clinical Trial in Pediatric Autism Spectrum Disorder.
Autism spectrum disorders
Biomarkers
Brain function
Brain structure
Clinical trial
Interventions–pharmacologic
Magnetic resonance imaging
Neuroimaging
Pre-school children
School-age children
Journal
Journal of autism and developmental disorders
ISSN: 1573-3432
Titre abrégé: J Autism Dev Disord
Pays: United States
ID NLM: 7904301
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
accepted:
14
04
2021
pubmed:
28
4
2021
medline:
22
2
2022
entrez:
27
4
2021
Statut:
ppublish
Résumé
There is an increasing interest in using magnetic resonance imaging (MRI) as a tool for precision medicine in autism spectrum disorder (ASD). This study investigated the feasibility of MRI scanning in a large comprehensive, inclusive and test heavy clinical trial for children (aged 3-12 years) with ASD, without functioning constraints for participation. Of the 71 participants enrolled who consented to the MRI, 24 participants (38%) successfully completed an MRI scan at baseline along with other assessments. This scanning followed a familiarization procedure at two preceding visits. At post-treatment, 21 participants successfully completed the MRI scan. This study highlights the challenge of completing MRI assessments in ASD populations when conducted as one of a number of tests in a clinical trial.
Identifiants
pubmed: 33903957
doi: 10.1007/s10803-021-05028-2
pii: 10.1007/s10803-021-05028-2
doi:
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1211-1222Subventions
Organisme : National Health and Medical Research Council
ID : 1043664
Organisme : National Health and Medical Research Council
ID : 1125449
Organisme : National Health and Medical Research Council (AU)
ID : APP1136259
Organisme : Research Training Program Australia
ID : SC0042/SC1999
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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