Substance use, Unlike Dolutegravir, is Associated with Mood Symptoms in People Living with HIV.
Anti-retroviral agents
Central nervous system
Depression
Dolutegravir
Impulsive behavior
Side effects
Journal
AIDS and behavior
ISSN: 1573-3254
Titre abrégé: AIDS Behav
Pays: United States
ID NLM: 9712133
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
accepted:
16
04
2021
pubmed:
28
4
2021
medline:
23
11
2021
entrez:
27
4
2021
Statut:
ppublish
Résumé
Contradictory data have been reported concerning neuropsychiatric side effects of the first-line antiretroviral drug dolutegravir, which may be partly due to lack of control groups or psychiatric assessment tools. Using validated self-report questionnaires, we compared mood and anxiety (DASS-42), impulsivity (BIS-11), and substance use (MATE-Q) between dolutegravir-treated and dolutegravir-naive people living with HIV (PLHIV). We analyzed 194, mostly male, PLHIV on long-term treatment of whom 82/194 (42.3%) used dolutegravir for a median (IQR) of 280 (258) days. Overall, 51/194 (26.3%) participants reported DASS-42 scores above the normal cut-off, 27/194 (13.5%) were classified as highly impulsive, and 58/194 (29.9%) regularly used recreational drugs. Regular substance use was positively associated with depression (p = 0.012) and stress scores (p = 0.045). We observed no differences between dolutegravir-treated and dolutegravir-naive PLHIV. Our data show that depressed and anxious moods and impulsivity are common in PLHIV and associate with substance use and not with dolutegravir use.
Identifiants
pubmed: 33903997
doi: 10.1007/s10461-021-03272-2
pii: 10.1007/s10461-021-03272-2
pmc: PMC8602138
doi:
Substances chimiques
Heterocyclic Compounds, 3-Ring
0
Oxazines
0
Piperazines
0
Pyridones
0
dolutegravir
DKO1W9H7M1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4094-4101Subventions
Organisme : Aidsfonds
ID : P-29001
Informations de copyright
© 2021. The Author(s).
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