Physiological responses during ascent to high altitude and the incidence of acute mountain sickness.

Adaptation, Physiological Adult Altitude Sickness / physiopathology Blood Pressure Exercise Female Heart Rate Humans Male Middle Aged Oxygen Saturation Respiratory Rate
altitude altitude sickness exercise hypoxia

Journal

Physiological reports
ISSN: 2051-817X
Titre abrégé: Physiol Rep
Pays: United States
ID NLM: 101607800

Informations de publication

Date de publication:
04 2021
Historique:
revised: 25 02 2021
received: 05 11 2020
accepted: 02 03 2021
pubmed: 28 4 2021
medline: 28 12 2021
entrez: 27 4 2021
Statut: ppublish

Résumé

Acute mountain sickness (AMS) occurs when there is failure of acclimatisation to high altitude. The aim of this study was to describe the relationship between physiological variables and the incidence of AMS during ascent to 5300 m. A total of 332 lowland-dwelling volunteers followed an identical ascent profile on staggered treks. Self-reported symptoms of AMS were recorded daily using the Lake Louise score (mild 3-4; moderate-severe ≥5), alongside measurements of physiological variables (heart rate, respiratory rate (RR), peripheral oxygen saturation (SpO

Identifiants

DOI: 10.14814/phy2.14809 PMID: 33904650 PMC: PMC8077104
pubmed: 33904650
doi: 10.14814/phy2.14809
pmc: PMC8077104
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e14809

Subventions

Organisme : Department of Health
Pays : United Kingdom

Investigateurs

V Ahuja (V)
G Aref-Adib (G)
R Burnham (R)
A Chisholm (A)
K Clarke (K)
D Coates (D)
M Coates (M)
D Cook (D)
M Cox (M)
S Dhillon (S)
C Dougall (C)
P Doyle (P)
P Duncan (P)
M Edsell (M)
L Edwards (L)
L Evans (L)
P Gardiner (P)
M Grocott (M)
P Gunning (P)
N Hart (N)
J Harrington (J)
J Harvey (J)
C Holloway (C)
D Howard (D)
D Hurlbut (D)
C Imray (C)
C Ince (C)
J van der Kaaij (J)
M Khosravi (M)
N Kolfschoten (N)
D Levett (D)
H Luery (H)
A Luks (A)
D Martin (D)
R McMorrow (R)
P Meale (P)
K Mitchell (K)
H Montgomery (H)
G Morgan (G)
J Morgan (J)
A Murray (A)
M Mythen (M)
S Newman (S)
M O'Dwyer (M)
J Pate (J)
T Plant (T)
M Pun (M)
P Richards (P)
A Richardson (A)
G Rodway (G)
J Simpson (J)
C Stroud (C)
M Stroud (M)
J Stygal (J)
B Symons (B)
P Szawarski (P)
A Van Tulleken (A)
C Van Tulleken (C)
A Vercueil (A)
L Wandrag (L)
M Wilson (M)
J Windsor (J)
B Basnyat (B)
C Clarke (C)
T Hornbein (T)
J Milledge (J)
J West (J)
S Abraham (S)
T Adams (T)
W Anseeuw (W)
R Astin (R)
B Basnyat (B)
O Burdall (O)
J Carroll (J)
A Cobb (A)
J Coppel (J)
O Couppis (O)
J Court (J)
A Cumpstey (A)
T Davies (T)
S Dhillon (S)
N Diamond (N)
C Dougall (C)
T Geliot (T)
E Gilbert-Kawai (E)
G Gilbert-Kawai (G)
E Gnaiger (E)
M Grocott (M)
C Haldane (C)
P Hennis (P)
J Horscroft (J)
D Howard (D)
S Jack (S)
B Jarvis (B)
W Jenner (W)
G Jones (G)
J van der Kaaij (J)
J Kenth (J)
A Kotwica (A)
R Kumar Bc (R)
J Lacey (J)
V Laner (V)
D Levett (D)
D Martin (D)
P Meale (P)
K Mitchell (K)
Z Mahomed (Z)
J Moonie (J)
A Murray (A)
M Mythen (M)
P Mythen (P)
K O'Brien (K)
I Ruggles-Brice (I)
K Salmon (K)
A Sheperdigian (A)
T Smedley (T)
B Symons (B)
C Tomlinson (C)
A Vercueil (A)
L Wandrag (L)
S Ward (S)
A Wight (A)
C Wilkinson (C)
S Wythe (S)
M Feelisch (M)
E Gilbert-Kawai (E)
M Grocott (M)
M Hanson (M)
D Levett (D)
D Martin (D)
K Mitchell (K)
H Montgomery (H)
R Moon (R)
A Murray (A)
M Mythen (M)
M Peters (M)

Informations de copyright

© 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.

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Auteurs

Alexandra B Cobb (AB)

University College London Centre for Altitude Space and Extreme Environment Medicine, UCLH NIHR Biomedical Research Centre, Institute of Sport and Exercise Health, London, UK.

Denny Z H Levett (DZH)

University College London Centre for Altitude Space and Extreme Environment Medicine, UCLH NIHR Biomedical Research Centre, Institute of Sport and Exercise Health, London, UK.
Anaesthesia and Critical Care Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Perioperative and Critical Care Research Theme, NIHR Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Integrative Physiology and Critical Illness Group, School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

Kay Mitchell (K)

University College London Centre for Altitude Space and Extreme Environment Medicine, UCLH NIHR Biomedical Research Centre, Institute of Sport and Exercise Health, London, UK.
Anaesthesia and Critical Care Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Perioperative and Critical Care Research Theme, NIHR Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Integrative Physiology and Critical Illness Group, School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

Wynne Aveling (W)

Anaesthetic Department, University College London Hospital, London, UK.

Daniel Hurlbut (D)

University College London Centre for Altitude Space and Extreme Environment Medicine, UCLH NIHR Biomedical Research Centre, Institute of Sport and Exercise Health, London, UK.

Edward Gilbert-Kawai (E)

University College London Centre for Altitude Space and Extreme Environment Medicine, UCLH NIHR Biomedical Research Centre, Institute of Sport and Exercise Health, London, UK.

Philip J Hennis (PJ)

University College London Centre for Altitude Space and Extreme Environment Medicine, UCLH NIHR Biomedical Research Centre, Institute of Sport and Exercise Health, London, UK.

Monty G Mythen (MG)

University College London Centre for Altitude Space and Extreme Environment Medicine, UCLH NIHR Biomedical Research Centre, Institute of Sport and Exercise Health, London, UK.

Michael P W Grocott (MPW)

University College London Centre for Altitude Space and Extreme Environment Medicine, UCLH NIHR Biomedical Research Centre, Institute of Sport and Exercise Health, London, UK.
Anaesthesia and Critical Care Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Perioperative and Critical Care Research Theme, NIHR Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Integrative Physiology and Critical Illness Group, School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
ORCID: 0000-0002-9484-7581

Daniel S Martin (DS)

University College London Centre for Altitude Space and Extreme Environment Medicine, UCLH NIHR Biomedical Research Centre, Institute of Sport and Exercise Health, London, UK.
Intensive Care Unit, University Hospitals Plymouth, Plymouth, UK.
Peninsula Medical School, University of Plymouth, Plymouth, UK.

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Classifications MeSH

questionsmedicales.fr › Phénomènes biologiques › Adaptation biologique › Adaptation physiologique › Physiological responses during ascent to high...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Physiological responses during ascent to high...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Troubles respiratoires › Mal de l'altitude › Physiological responses during ascent to high...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Pression sanguine › Physiological responses during ascent to high...
questionsmedicales.fr › Activités humaines › Exercice physique › Physiological responses during ascent to high...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Rythme cardiaque › Physiological responses during ascent to high...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Physiological responses during ascent to high...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Physiological responses during ascent to high...
questionsmedicales.fr › Métabolisme › Saturation en oxygène › Physiological responses during ascent to high...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques respiratoires › Respiration › Fréquence respiratoire › Physiological responses during ascent to high...