Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-X

Animals Antineoplastic Agents / chemistry Binding Sites Biphenyl Compounds / chemistry Cell Line Cell Survival / drug effects Crystallography, X-Ray Humans Hydrophobic and Hydrophilic Interactions Inhibitory Concentration 50 Mice Molecular Dynamics Simulation Nitrophenols / chemistry Piperazines / chemistry Protein Binding Proto-Oncogene Proteins c-bcl-2 / antagonists & inhibitors Structure-Activity Relationship Sulfonamides / chemistry Surface Plasmon Resonance Urea / analogs & derivatives bcl-X Protein / antagonists & inhibitors

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
13 05 2021
Historique:
pubmed: 28 4 2021
medline: 17 6 2021
entrez: 27 4 2021
Statut: ppublish

Résumé

The BCL-2 family of proteins (including the prosurvival proteins BCL-2, BCL-X

Identifiants

DOI: 10.1021/acs.jmedchem.0c01771 PMID: 33904752
pubmed: 33904752
doi: 10.1021/acs.jmedchem.0c01771
doi:

Substances chimiques

ABT-737 0
Antineoplastic Agents 0
Biphenyl Compounds 0
Nitrophenols 0
Piperazines 0
Proto-Oncogene Proteins c-bcl-2 0
Sulfonamides 0
bcl-X Protein 0
Urea 8W8T17847W

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

5447-5469

Auteurs

Michael J Roy (MJ)

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.
Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia.
ORCID: 0000-0003-0198-9108

Amelia Vom (A)

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.
Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia.

Toru Okamoto (T)

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.
Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia.

Brian J Smith (BJ)

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.
Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia.
ORCID: 0000-0003-0498-1910

Richard W Birkinshaw (RW)

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.
Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia.

Hong Yang (H)

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.
Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia.

Houda Abdo (H)

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.
Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia.

Christine A White (CA)

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.
Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia.

David Segal (D)

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.

David C S Huang (DCS)

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.
Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia.

Jonathan B Baell (JB)

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.
Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia.
ORCID: 0000-0003-2114-8242

Peter M Colman (PM)

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.
Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia.

Peter E Czabotar (PE)

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.
Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia.

Guillaume Lessene (G)

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.
Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia.
Department of Pharmacology and Therapeutics, The University of Melbourne, Parkville, VIC 3050, Australia.
ORCID: 0000-0002-1193-8147

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Structure-Guided Development of Potent...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Structure-Guided Development of Potent...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Structure-Guided Development of Potent...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Dérivés du biphényle › Structure-Guided Development of Potent...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Structure-Guided Development of Potent...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Structure-Guided Development of Potent...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › Structure-Guided Development of Potent...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Structure-Guided Development of Potent...
questionsmedicales.fr › Phénomènes chimiques › Interactions hydrophobes et hydrophiles › Structure-Guided Development of Potent...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Concentration inhibitrice 50 › Structure-Guided Development of Potent...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Structure-Guided Development of Potent...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › Structure-Guided Development of Potent...
questionsmedicales.fr › Composés chimiques organiques › Composés nitrés › Nitrophénols › Structure-Guided Development of Potent...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipérazines › Structure-Guided Development of Potent...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Structure-Guided Development of Potent...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-bcl-2 › Structure-Guided Development of Potent...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Structure-Guided Development of Potent...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfones › Sulfonamides › Structure-Guided Development of Potent...
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Techniques de biocapteur › Résonance plasmonique de surface › Structure-Guided Development of Potent...
questionsmedicales.fr › Composés chimiques organiques › Amides › Urée › Structure-Guided Development of Potent...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Protéine bcl-X › Structure-Guided Development of Potent...