Treating lymphoma is now a bit EZ-er.
Journal
Blood advances
ISSN: 2473-9537
Titre abrégé: Blood Adv
Pays: United States
ID NLM: 101698425
Informations de publication
Date de publication:
27 04 2021
27 04 2021
Historique:
received:
01
10
2020
accepted:
08
03
2021
entrez:
27
4
2021
pubmed:
28
4
2021
medline:
1
6
2021
Statut:
ppublish
Résumé
Tazemetostat represents the first epigenetic therapy approved for the treatment of follicular lymphoma (FL). It inhibits the activity of the enhancer of zeste homolog 2 (EZH2) histone methyltransferase, the first of a multitude of epigenetic regulators that have been identified as recurrently mutated in FL and germinal center diffuse large B-cell lymphoma. In this review, we discuss the initial discovery and ongoing exploration of the functional role of EZH2 mutations in lymphomagenesis. We also explore the path from the preclinical development of tazemetostat to its approval for the treatment of relapsed FL, and potential future therapeutic applications. We discuss the clinical data that led to the approval of tazemetostat and ongoing research into the function of EZH2 and of tazemetostat in lymphomas that derive from the germinal center, which could increase the applicability of this drug in the future.
Identifiants
pubmed: 33904892
pii: S2473-9529(21)00286-X
doi: 10.1182/bloodadvances.2020002773
pmc: PMC8095133
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2256-2263Informations de copyright
© 2021 by The American Society of Hematology.
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