Human Endogenous Retroviruses as Biomedicine Markers.
Biomedicine marker
Cancer
Disease
Human endogenous retrovirus (HERVs)
Viral infection
Journal
Virologica Sinica
ISSN: 1995-820X
Titre abrégé: Virol Sin
Pays: Netherlands
ID NLM: 101514185
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
22
08
2020
accepted:
15
03
2021
pubmed:
28
4
2021
medline:
3
11
2021
entrez:
27
4
2021
Statut:
ppublish
Résumé
Human endogenous retroviruses (HERVs) were formed via ancient integration of exogenous retroviruses into the human genome and are considered to be viral "fossils". The human genome is embedded with a considerable amount of HERVs, witnessing the long-term evolutionary history of the viruses and the host. Most HERVs have lost coding capability during selection but still function in terms of HERV-mediated regulation of host gene expression. In this review, we summarize the roles of HERV activation in response to viral infections and diseases, and emphasize the potential use of HERVs as biomedicine markers in the early diagnosis of diseases such as cancer, which provides a new perspective for the clinical application of HERVs.
Identifiants
pubmed: 33905075
doi: 10.1007/s12250-021-00387-7
pii: 10.1007/s12250-021-00387-7
pmc: PMC8558139
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
852-858Informations de copyright
© 2021. Wuhan Institute of Virology, CAS.
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