The Effect of a Single Bout of Continuous Aerobic Exercise on Glucose, Insulin and Glucagon Concentrations Compared to Resting Conditions in Healthy Adults: A Systematic Review, Meta-Analysis and Meta-Regression.
Journal
Sports medicine (Auckland, N.Z.)
ISSN: 1179-2035
Titre abrégé: Sports Med
Pays: New Zealand
ID NLM: 8412297
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
accepted:
08
04
2021
pubmed:
28
4
2021
medline:
26
10
2021
entrez:
27
4
2021
Statut:
ppublish
Résumé
Elevated glucose and insulin levels are major risk factors in the development of cardiometabolic disease. Aerobic exercise is widely recommended to improve glycaemic control, yet its acute effect on glycaemia and glucoregulatory hormones has not been systematically reviewed and analysed in healthy adults. To determine the effect of a single bout of continuous aerobic exercise on circulating glucose, insulin, and glucagon concentrations in healthy adults. CENTRAL, CINAHL, Embase, Global Health, HMIC, Medline, PubMed, PsycINFO, ScienceDirect, Scopus and Web of Science databases were searched from inception to May 2020. Papers were included if they reported a randomised, crossover study measuring glucose and/or insulin and/or glucagon concentrations before and immediately after a single bout of continuous aerobic exercise (≥ 30 min) compared to a time-matched, resting control arm in healthy adults. The risk of bias and quality of evidence were assessed using the Cochrane Risk of Bias Tool and GRADE approach, respectively. Random-effects meta-analyses were performed for glucose, insulin, and glucagon. Sub-group meta-analyses and meta-regression were performed for categorical (metabolic state [postprandial or fasted], exercise mode [cycle ergometer or treadmill]) and continuous (age, body mass index, % males, maximal aerobic capacity, exercise duration, exercise intensity) covariates, respectively. 42 papers (51 studies) were considered eligible: glucose (45 studies, 391 participants), insulin (38 studies, 377 participants) and glucagon (5 studies, 47 participants). Acute aerobic exercise had no significant effect on glucose concentrations (mean difference: - 0.05 mmol/L; 95% CI, - 0.22 to 0.13 mmol/L; P = 0.589; I Acute aerobic exercise performed in the postprandial state decreases glucose and insulin concentrations in healthy adults. Acute aerobic exercise also increases glucagon concentrations irrespective of metabolic state. Therefore, aerobic exercise undertaken in the postprandial state is an effective strategy to improve acute glycaemic control in healthy adults, supporting the role of aerobic exercise in reducing cardiometabolic disease incidence. CRD42020191345.
Sections du résumé
BACKGROUND
Elevated glucose and insulin levels are major risk factors in the development of cardiometabolic disease. Aerobic exercise is widely recommended to improve glycaemic control, yet its acute effect on glycaemia and glucoregulatory hormones has not been systematically reviewed and analysed in healthy adults.
OBJECTIVE
To determine the effect of a single bout of continuous aerobic exercise on circulating glucose, insulin, and glucagon concentrations in healthy adults.
METHODS
CENTRAL, CINAHL, Embase, Global Health, HMIC, Medline, PubMed, PsycINFO, ScienceDirect, Scopus and Web of Science databases were searched from inception to May 2020. Papers were included if they reported a randomised, crossover study measuring glucose and/or insulin and/or glucagon concentrations before and immediately after a single bout of continuous aerobic exercise (≥ 30 min) compared to a time-matched, resting control arm in healthy adults. The risk of bias and quality of evidence were assessed using the Cochrane Risk of Bias Tool and GRADE approach, respectively. Random-effects meta-analyses were performed for glucose, insulin, and glucagon. Sub-group meta-analyses and meta-regression were performed for categorical (metabolic state [postprandial or fasted], exercise mode [cycle ergometer or treadmill]) and continuous (age, body mass index, % males, maximal aerobic capacity, exercise duration, exercise intensity) covariates, respectively.
RESULTS
42 papers (51 studies) were considered eligible: glucose (45 studies, 391 participants), insulin (38 studies, 377 participants) and glucagon (5 studies, 47 participants). Acute aerobic exercise had no significant effect on glucose concentrations (mean difference: - 0.05 mmol/L; 95% CI, - 0.22 to 0.13 mmol/L; P = 0.589; I
CONCLUSIONS
Acute aerobic exercise performed in the postprandial state decreases glucose and insulin concentrations in healthy adults. Acute aerobic exercise also increases glucagon concentrations irrespective of metabolic state. Therefore, aerobic exercise undertaken in the postprandial state is an effective strategy to improve acute glycaemic control in healthy adults, supporting the role of aerobic exercise in reducing cardiometabolic disease incidence.
PROSPERO REGISTRATION NUMBER
CRD42020191345.
Identifiants
pubmed: 33905087
doi: 10.1007/s40279-021-01473-2
pii: 10.1007/s40279-021-01473-2
pmc: PMC8363558
doi:
Substances chimiques
Blood Glucose
0
Insulin
0
Glucagon
9007-92-5
Glucose
IY9XDZ35W2
Types de publication
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1949-1966Informations de copyright
© 2021. The Author(s).
Références
J Endocrinol. 2007 May;193(2):251-8
pubmed: 17470516
Nutr Metab (Lond). 2011 Sep 24;8:66
pubmed: 21943373
Br J Nutr. 2017 May;117(10):1414-1421
pubmed: 28615090
J Clin Epidemiol. 2009 Oct;62(10):e1-34
pubmed: 19631507
J Endocrinol. 2009 Dec;203(3):357-64
pubmed: 19737911
Int J Sport Nutr Exerc Metab. 2017 Oct;27(5):389-398
pubmed: 28657803
Med Sci Sports Exerc. 2008 Jul;40(7):1271-6
pubmed: 18580407
Metabolites. 2019 Jun 15;9(6):
pubmed: 31208054
Appl Physiol Nutr Metab. 2011 Dec;36(6):958-66
pubmed: 22111518
Med Sci Sports Exerc. 2010 Mar;42(3):485-92
pubmed: 19952806
J Clin Invest. 1986 Mar;77(3):900-7
pubmed: 2869053
Appl Physiol Nutr Metab. 2019 Oct;44(10):1065-1072
pubmed: 31453723
J Appl Physiol (1985). 2013 Sep 1;115(5):618-25
pubmed: 23788577
Clin Physiol Funct Imaging. 2011 May;31(3):215-20
pubmed: 21470361
Sports Med. 2009;39(3):179-206
pubmed: 19290675
Scand J Med Sci Sports. 2018 Mar;28(3):939-946
pubmed: 29059510
Eur J Appl Physiol. 2013 Mar;113(3):775-83
pubmed: 22971724
Nat Rev Endocrinol. 2017 Mar;13(3):133-148
pubmed: 27739515
Front Endocrinol (Lausanne). 2020 Aug 04;11:495
pubmed: 32849285
BMJ. 2008 Apr 26;336(7650):924-6
pubmed: 18436948
J Appl Physiol (1985). 2002 Jul;93(1):384-92
pubmed: 12070228
J Physiol. 2005 Nov 1;568(Pt 3):941-50
pubmed: 16020461
Br J Nutr. 2013 Aug;110(4):721-32
pubmed: 23340006
Chronobiol Int. 2010 May;27(3):590-605
pubmed: 20524803
Ann Intern Med. 1999 Jan 19;130(2):89-96
pubmed: 10068380
Peptides. 2015 Sep;71:94-9
pubmed: 26188172
Sports Med. 2014 Mar;44(3):387-403
pubmed: 24174308
Stat Med. 2002 Nov 15;21(21):3153-9
pubmed: 12375296
J Sci Med Sport. 2020 Oct;23(10):902-907
pubmed: 32173259
Prog Mol Biol Transl Sci. 2015;135:203-25
pubmed: 26477916
Eur J Appl Physiol Occup Physiol. 1996;74(1-2):36-43
pubmed: 8891498
Int J Sports Med. 1991 Dec;12(6):537-42
pubmed: 1797694
J Endocrinol. 2009 Apr;201(1):151-9
pubmed: 19158129
J Clin Epidemiol. 2008 Oct;61(10):991-6
pubmed: 18538991
Eur J Appl Physiol. 2008 Feb;102(3):361-70
pubmed: 17952452
Int J Sports Med. 1991 Aug;12(4):379-83
pubmed: 1917222
Am Heart J. 2006 Jul;152(1):27-38
pubmed: 16824829
Diabetes Care. 2016 Nov;39(11):2065-2079
pubmed: 27926890
Sports Med. 2015 Apr;45(4):587-99
pubmed: 25616852
Eur J Appl Physiol. 2007 May;100(2):225-34
pubmed: 17323071
Diabetes Care. 2015 May;38(5):921-9
pubmed: 25784661
Circulation. 2004 Jul 13;110(2):214-9
pubmed: 15197140
J Cardiovasc Risk. 1995 Feb;2(1):71-8
pubmed: 7606644
Res Synth Methods. 2010 Apr;1(2):97-111
pubmed: 26061376
Arch Intern Med. 2005 Sep 12;165(16):1910-6
pubmed: 16157837
J Sports Sci. 2007 Apr;25(6):635-42
pubmed: 17454530
Appl Physiol Nutr Metab. 2013 Jan;38(1):66-72
pubmed: 23368830
Int J Sports Med. 1994 Jul;15(5):228-31
pubmed: 7960315
Appl Physiol Nutr Metab. 2014 Nov;39(11):1222-9
pubmed: 25068791
Lipids Health Dis. 2007 Oct 31;6:30
pubmed: 17973988
J Appl Physiol (1985). 2002 Jun;92(6):2547-53
pubmed: 12015372
Diabetol Metab Syndr. 2009 Sep 21;1(1):8
pubmed: 19825145
J Endocrinol. 2017 Mar;232(3):411-422
pubmed: 27999089
Sports Med. 2012 Dec 1;42(12):1059-80
pubmed: 23134339
Int J Obes Relat Metab Disord. 1999 Oct;23(10):1047-56
pubmed: 10557025
J Appl Physiol (1985). 2001 Nov;91(5):2125-34
pubmed: 11641353
Nat Rev Endocrinol. 2020 Dec;16(12):683-696
pubmed: 32963340
Eur J Endocrinol. 2007 Nov;157(5):613-23
pubmed: 17984241
Metabolism. 1987 Aug;36(8):726-30
pubmed: 3298940
Diabetes Care. 2013 May;36(5):1229-35
pubmed: 23275353
J Clin Endocrinol Metab. 2010 Sep;95(9):E64-8
pubmed: 20534752
Clin Physiol. 1997 Jan;17(1):19-30
pubmed: 9015655
Diabetes. 1982 Mar;31(3):212-6
pubmed: 6759238
Nutrients. 2018 Jun 19;10(6):
pubmed: 29921786
Nat Rev Endocrinol. 2020 Sep;16(9):495-505
pubmed: 32632275
J Clin Epidemiol. 1992 Jul;45(7):769-73
pubmed: 1619456
J Appl Physiol (1985). 2002 Aug;93(2):788-96
pubmed: 12133893
Med Sci Sports Exerc. 2001 Apr;33(4):568-75
pubmed: 11283432
Diabetes. 1997 Apr;46(4):701-10
pubmed: 9075814
Int J Obes (Lond). 2017 Dec;41(12):1737-1744
pubmed: 28769121
J Sport Health Sci. 2016 Sep;5(3):342-348
pubmed: 30356500
Br J Nutr. 2013 Jun 28;109(12):2297-307
pubmed: 23167985
Acta Physiol Scand. 2005 Apr;183(4):345-56
pubmed: 15799771
Int J Sport Nutr Exerc Metab. 2020 Jan 1;30(1):2-13
pubmed: 31945740
Med Sci Sports Exerc. 1998 May;30(5):671-8
pubmed: 9588607
Obesity (Silver Spring). 2009 Mar;17(3):559-63
pubmed: 19131940
Br J Nutr. 2004 May;91(5):683-7
pubmed: 15137919
Acta Physiol Scand. 1991 Sep;143(1):105-15
pubmed: 1957696
Am J Physiol Endocrinol Metab. 2015 Dec 15;309(12):E949-59
pubmed: 26487009
Horm Metab Res. 2003 Feb;35(2):97-103
pubmed: 12734789
Acta Endocrinol (Copenh). 1990 Jul;123(1):30-6
pubmed: 2202174