Orthogonal Demethylase-Activated Deoxyribozyme for Intracellular Imaging and Gene Regulation.

DNA / chemistry DNA, Catalytic / chemistry Epigenesis, Genetic / genetics Gene Expression Regulation Humans MCF-7 Cells Molecular Structure Optical Imaging

Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
12 05 2021
Historique:
pubmed: 28 4 2021
medline: 15 12 2021
entrez: 27 4 2021
Statut: ppublish

Résumé

The epigenetic modification of nucleic acids represents a versatile approach for achieving high-efficient control over gene expression and transcription and could dramatically expand their biosensing and therapeutic applications. Demethylase-involved removal of N6-methyladenine (m

Identifiants

DOI: 10.1021/jacs.1c00570 PMID: 33905655
pubmed: 33905655
doi: 10.1021/jacs.1c00570
doi:

Substances chimiques

DNA, Catalytic 0
DNA 9007-49-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6895-6904

Auteurs

Qing Wang (Q)

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China.

Kaiyue Tan (K)

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China.

Hong Wang (H)

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China.

Jinhua Shang (J)

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China.

Yeqing Wan (Y)

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China.

Xiaoqing Liu (X)

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China.
ORCID: 0000-0002-1309-5454

Xiaocheng Weng (X)

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China.
ORCID: 0000-0002-0605-8495

Fuan Wang (F)

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China.
ORCID: 0000-0002-3063-2485

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Orthogonal Demethylase-Activated Deoxyribozyme...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN catalytique › Orthogonal Demethylase-Activated Deoxyribozyme...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Orthogonal Demethylase-Activated Deoxyribozyme...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Orthogonal Demethylase-Activated Deoxyribozyme...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Orthogonal Demethylase-Activated Deoxyribozyme...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Cellules MCF-7 › Orthogonal Demethylase-Activated Deoxyribozyme...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Orthogonal Demethylase-Activated Deoxyribozyme...
questionsmedicales.fr › Techniques d'investigation › Imagerie optique › Orthogonal Demethylase-Activated Deoxyribozyme...