Oxidation-Sensitive Core-Multishell Nanocarriers for the Controlled Delivery of Hydrophobic Drugs.

Dexamethasone Drug Carriers Drug Delivery Systems Humans Nanoparticles Oxidation-Reduction
AFM-IR CMS nanocarriers Nile Red anti-inflammatory drugs dexamethasone mTHPP oxidation rapamycin redox skin penetration stimuli-triggered thioether

Journal

ACS biomaterials science & engineering
ISSN: 2373-9878
Titre abrégé: ACS Biomater Sci Eng
Pays: United States
ID NLM: 101654670

Informations de publication

Date de publication:
14 06 2021
Historique:
pubmed: 28 4 2021
medline: 22 6 2021
entrez: 27 4 2021
Statut: ppublish

Résumé

A synthetic route for oxidation-sensitive core-multishell (osCMS) nanocarriers was established, and their drug loading and release properties were analyzed based on their structural variations. The nanocarriers showed a drug loading of 0.3-3 wt % for the anti-inflammatory drugs rapamycin and dexamethasone and the photosensitizer

Identifiants

DOI: 10.1021/acsbiomaterials.0c01771 PMID: 33905661
pubmed: 33905661
doi: 10.1021/acsbiomaterials.0c01771
doi:

Substances chimiques

Drug Carriers 0
Dexamethasone 7S5I7G3JQL

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2485-2495

Auteurs

Keerthana Rajes (K)

Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3 and Arnimalle 22, 14195 Berlin, Germany.

Karolina A Walker (KA)

Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3 and Arnimalle 22, 14195 Berlin, Germany.

Sabrina Hadam (S)

Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité-Universitaetsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.

Fatemeh Zabihi (F)

Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3 and Arnimalle 22, 14195 Berlin, Germany.
Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité-Universitaetsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.

Jumana Ibrahim-Bacha (J)

Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3 and Arnimalle 22, 14195 Berlin, Germany.

Gregor Germer (G)

Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3 and Arnimalle 22, 14195 Berlin, Germany.

Piotr Patoka (P)

Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3 and Arnimalle 22, 14195 Berlin, Germany.

Bernhard Wassermann (B)

Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3 and Arnimalle 22, 14195 Berlin, Germany.

Fiorenza Rancan (F)

Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité-Universitaetsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
ORCID: 0000-0003-3903-3240

Eckart Rühl (E)

Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3 and Arnimalle 22, 14195 Berlin, Germany.
ORCID: 0000-0002-0451-8734

Annika Vogt (A)

Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité-Universitaetsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.

Rainer Haag (R)

Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3 and Arnimalle 22, 14195 Berlin, Germany.
ORCID: 0000-0003-3840-162X

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Classifications MeSH

questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Stéroïdes fluorés › Dexaméthasone › Oxidation-Sensitive Core-Multishell...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Vecteurs de médicaments › Oxidation-Sensitive Core-Multishell...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Oxidation-Sensitive Core-Multishell...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Oxidation-Sensitive Core-Multishell...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Oxidation-Sensitive Core-Multishell...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Oxidation-Sensitive Core-Multishell...