Alisol A 24-acetate protects oxygen-glucose deprivation-induced brain microvascular endothelial cells against apoptosis through miR-92a-3p inhibition by targeting the
Animals
Apoptosis
/ drug effects
Brain
/ cytology
Cell Survival
/ drug effects
Cells, Cultured
Cholestenones
/ administration & dosage
Endothelial Cells
/ drug effects
Glucose
/ metabolism
Inhibitory Concentration 50
Mice
MicroRNAs
/ genetics
Oxygen
/ metabolism
Protective Agents
/ administration & dosage
Proto-Oncogene Proteins c-bcl-2
/ genetics
BMECs
Bcl-2
MicroRNA-92a-3p
Journal
Pharmaceutical biology
ISSN: 1744-5116
Titre abrégé: Pharm Biol
Pays: England
ID NLM: 9812552
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
entrez:
27
4
2021
pubmed:
28
4
2021
medline:
19
11
2021
Statut:
ppublish
Résumé
Alisol A 24-acetate has been used to treat vascular diseases. However, the underlying mechanisms still remain unclear. The present study evaluated the antiapoptotic effect of alisol A 24-acetate on brain microvascular endothelial cells (BMECs) and explored the underlying mechanisms. BMECs were injured through oxygen -glucose deprivation (OGD) after alisol A 24-acetate treatment. Cell viability and half-maximal inhibitory concentration (IC Alisol A 24-acetate had an IC These findings suggest that alisol A 24-acetate exerts antiapoptotic effects on OGD-induced BMECs through miR-92a-3p inhibition by targeting the Bcl-2 gene, indicating its potential for BMECs protection and as a novel therapeutic agent for the treatment of cerebrovascular disease.
Identifiants
pubmed: 33905668
doi: 10.1080/13880209.2021.1912117
pmc: PMC8081307
doi:
Substances chimiques
Cholestenones
0
MicroRNAs
0
Mirn92 microRNA, mouse
0
Protective Agents
0
Proto-Oncogene Proteins c-bcl-2
0
alisol A 24-acetate
0
Glucose
IY9XDZ35W2
Oxygen
S88TT14065
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
513-524Références
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