Neuronal activation of the sexually dimorphic nucleus of the preoptic area in female and male rats during copulation and its sex differences.
Calbindin-D28K
Preoptic area
Rats
Sexual behavior
Sexually dimorphic nucleus
c-Fos
Journal
Neuroscience letters
ISSN: 1872-7972
Titre abrégé: Neurosci Lett
Pays: Ireland
ID NLM: 7600130
Informations de publication
Date de publication:
11 06 2021
11 06 2021
Historique:
received:
01
02
2021
revised:
15
04
2021
accepted:
21
04
2021
pubmed:
28
4
2021
medline:
15
12
2021
entrez:
27
4
2021
Statut:
ppublish
Résumé
The medial preoptic area, which plays an essential role in the control of sexual behavior in rats, contains a sexually dimorphic nucleus that consists of neurons expressing calbindin-D28 K (Calb) that is referred to as the CALB-SDN. The CALB-SDN is larger and contains more Calb neurons in males than in females. The physiological functions of the CALB-SDN are not fully understood; however, CALB-SDN neurons are activated during sexual behavior in males, suggesting that the male CALB-SDN is involved in regulation of sexual behavior. However, no information exists about the physiological functions of the female CALB-SDN. In the present study, we performed an immunohistochemical analysis of c-Fos, a neuronal activity marker, in the CALB-SDN of female and male rats that had copulated with conspecifics of the opposite sex to determine whether neurons of the female CALB-SDN are activated during copulation and whether the neuronal activity of the CALB-SDN differs between sexes. The numbers of c-Fos-immunoreactive cells with or without Calb-immunoreactivity (c-Fos
Identifiants
pubmed: 33905774
pii: S0304-3940(21)00293-7
doi: 10.1016/j.neulet.2021.135915
pii:
doi:
Substances chimiques
Calbindins
0
Proto-Oncogene Proteins c-fos
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
135915Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.