InspirerMundi-Remote Monitoring of Inhaled Medication Adherence through Objective Verification Based on Combined Image Processing Techniques.


Journal

Methods of information in medicine
ISSN: 2511-705X
Titre abrégé: Methods Inf Med
Pays: Germany
ID NLM: 0210453

Informations de publication

Date de publication:
06 2021
Historique:
pubmed: 28 4 2021
medline: 29 10 2021
entrez: 27 4 2021
Statut: ppublish

Résumé

The adherence to inhaled controller medications is of critical importance for achieving good clinical results in patients with chronic respiratory diseases. Self-management strategies can result in improved health outcomes and reduce unscheduled care and improve disease control. However, adherence assessment suffers from difficulties on attaining a high grade of trustworthiness given that patient self-reports of high-adherence rates are known to be unreliable. Aiming to increase patient adherence to medication and allow for remote monitoring by health professionals, a mobile gamified application was developed where a therapeutic plan provides insight for creating a patient-oriented self-management system. To allow a reliable adherence measurement, the application includes a novel approach for objective verification of inhaler usage based on real-time video capture of the inhaler's dosage counters. This approach uses template matching image processing techniques, an off-the-shelf machine learning framework, and was developed to be reusable within other applications. The proposed approach was validated by 24 participants with a set of 12 inhalers models. Performed tests resulted in the correct value identification for the dosage counter in 79% of the registration events with all inhalers and over 90% for the three most widely used inhalers in Portugal. These results show the potential of exploring mobile-embedded capabilities for acquiring additional evidence regarding inhaler adherence. This system helps to bridge the gap between the patient and the health professional. By empowering the first with a tool for disease self-management and medication adherence and providing the later with additional relevant data, it paves the way to a better-informed disease management decision.

Sections du résumé

BACKGROUND
The adherence to inhaled controller medications is of critical importance for achieving good clinical results in patients with chronic respiratory diseases. Self-management strategies can result in improved health outcomes and reduce unscheduled care and improve disease control. However, adherence assessment suffers from difficulties on attaining a high grade of trustworthiness given that patient self-reports of high-adherence rates are known to be unreliable.
OBJECTIVE
Aiming to increase patient adherence to medication and allow for remote monitoring by health professionals, a mobile gamified application was developed where a therapeutic plan provides insight for creating a patient-oriented self-management system. To allow a reliable adherence measurement, the application includes a novel approach for objective verification of inhaler usage based on real-time video capture of the inhaler's dosage counters.
METHODS
This approach uses template matching image processing techniques, an off-the-shelf machine learning framework, and was developed to be reusable within other applications. The proposed approach was validated by 24 participants with a set of 12 inhalers models.
RESULTS
Performed tests resulted in the correct value identification for the dosage counter in 79% of the registration events with all inhalers and over 90% for the three most widely used inhalers in Portugal. These results show the potential of exploring mobile-embedded capabilities for acquiring additional evidence regarding inhaler adherence.
CONCLUSION
This system helps to bridge the gap between the patient and the health professional. By empowering the first with a tool for disease self-management and medication adherence and providing the later with additional relevant data, it paves the way to a better-informed disease management decision.

Identifiants

pubmed: 33906260
doi: 10.1055/s-0041-1726277
pmc: PMC8294936
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e9-e19

Informations de copyright

The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

Déclaration de conflit d'intérêts

R.A. reports grants from FCT (Fundação para a Ciência e a Tecnologia), during the conduct of the study. No additional conflict of interest to be reported.

Références

Lancet Respir Med. 2020 Jun;8(6):585-596
pubmed: 32526187
Lancet. 2017 Sep 16;390(10100):1151-1210
pubmed: 28919116
Prim Care Respir J. 2009 Dec;18(4):343-5
pubmed: 19940961
J Int Assoc Physicians AIDS Care (Chic). 2009 Nov-Dec;8(6):367-74
pubmed: 19952289
Am J Respir Crit Care Med. 2010 Mar 15;181(6):566-77
pubmed: 20019345
Pharmacoepidemiol Drug Saf. 2004 Jan;13(1):11-9
pubmed: 14971118
BMC Med Res Methodol. 2011 Nov 03;11:149
pubmed: 22050830
Eur Respir J. 2011 Feb;37(2):310-7
pubmed: 20562122
Cad Saude Publica. 2017 Apr 20;33(3):e00136216
pubmed: 28444026
J Med Internet Res. 2016 May 16;18(5):e97
pubmed: 27185295
Eur Respir J. 2017 May 19;49(5):
pubmed: 28526801
Eur Respir J. 2008 Jan;31(1):143-78
pubmed: 18166595
Lancet. 2003 Mar 29;361(9363):1071-6
pubmed: 12672309
J Allergy Clin Immunol Pract. 2019 May - Jun;7(5):1488-1496.e7
pubmed: 30639604
PLoS One. 2014 Jun 06;9(6):e98701
pubmed: 24905012
Prev Med Rep. 2018 Oct 19;12:284-293
pubmed: 30406006
PLoS One. 2017 Oct 9;12(10):e0185453
pubmed: 28991903
IEEE Trans Pattern Anal Mach Intell. 1986 Jun;8(6):679-98
pubmed: 21869365
JMIR Mhealth Uhealth. 2017 Aug 02;5(8):e113
pubmed: 28768606
Chron Respir Dis. 2017 Nov;14(4):407-419
pubmed: 27512084
Chron Respir Dis. 2017 Aug;14(3):309-320
pubmed: 28774201
BMC Med. 2017 Mar 17;15(1):64
pubmed: 28302126
J Allergy Clin Immunol Pract. 2016 Jul-Aug;4(4):730-737.e1
pubmed: 27107690
Asthma Res Pract. 2017 Jan 6;3:1
pubmed: 28078100
Eur Respir J. 2017 May 1;49(5):
pubmed: 28461306
J Med Internet Res. 2015 Feb 24;17(2):e52
pubmed: 25803266
Med Devices (Auckl). 2015 Feb 12;8:131-9
pubmed: 25709510
Eur Respir J. 2017 May 1;49(5):
pubmed: 28461291
Allergy. 2006 Mar;61(3):389-90
pubmed: 16436151
BMC Pulm Med. 2013 Mar 22;13:15
pubmed: 23517484
Clin Transl Allergy. 2019 Sep 23;9:47
pubmed: 31559008
Prev Med. 2014 Dec;69:95-107
pubmed: 25172024
Eur Respir J. 2015 Feb;45(2):396-407
pubmed: 25323234
Sci Rep. 2018 Feb 1;8(1):2164
pubmed: 29391489
Comput Intell Neurosci. 2014;2014:919406
pubmed: 24812556
Allergy. 2010 Aug;65(8):1042-8
pubmed: 20121755
BMJ Open. 2019 Nov 7;9(11):e031732
pubmed: 31699737
Biomed Res Int. 2015;2015:217047
pubmed: 26539470
Am J Respir Crit Care Med. 2001 Oct 15;164(8 Pt 1):1392-7
pubmed: 11704584
J Allergy Clin Immunol Pract. 2015 May-Jun;3(3):335-49.e1-5
pubmed: 25840665
BMJ Open Respir Res. 2016 Mar 14;3(1):e000128
pubmed: 27026805
BMJ Open Respir Res. 2016 Nov 29;3(1):e000159
pubmed: 27933181
Internet Interv. 2016 Nov 02;6:89-106
pubmed: 30135818

Auteurs

Pedro Vieira-Marques (P)

CINTESIS-Center for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal.

Rute Almeida (R)

CINTESIS-Center for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal.
Department of Community Medicine, MEDCIDS, Health Information and Decision, Faculty of Medicine, University of Porto, Porto, Portugal.

João F Teixeira (JF)

INESC TEC, Porto, Portugal.

José Valente (J)

MEDIDA-Serviços em Medicina, EDucação, Investigação, Desenvolvimento e Avaliação, LDA, Porto, Portugal.

Cristina Jácome (C)

CINTESIS-Center for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal.
Department of Community Medicine, MEDCIDS, Health Information and Decision, Faculty of Medicine, University of Porto, Porto, Portugal.

Afonso Cachim (A)

Department of Community Medicine, MEDCIDS, Health Information and Decision, Faculty of Medicine, University of Porto, Porto, Portugal.

Rui Guedes (R)

Department of Community Medicine, MEDCIDS, Health Information and Decision, Faculty of Medicine, University of Porto, Porto, Portugal.

Ana Pereira (A)

CINTESIS-Center for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal.
Department of Community Medicine, MEDCIDS, Health Information and Decision, Faculty of Medicine, University of Porto, Porto, Portugal.
Allergy Unit, Instituto and Hospital CUF, Porto, Portugal.

Tiago Jacinto (T)

CINTESIS-Center for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal.
MEDIDA-Serviços em Medicina, EDucação, Investigação, Desenvolvimento e Avaliação, LDA, Porto, Portugal.
Department of Cardiovascular and Respiratory Sciences, Porto Health School, Polytechnic Institute of Porto, Porto, Portugal.

João A Fonseca (JA)

CINTESIS-Center for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal.
Department of Community Medicine, MEDCIDS, Health Information and Decision, Faculty of Medicine, University of Porto, Porto, Portugal.
MEDIDA-Serviços em Medicina, EDucação, Investigação, Desenvolvimento e Avaliação, LDA, Porto, Portugal.
Allergy Unit, Instituto and Hospital CUF, Porto, Portugal.

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