Metallobiochemistry of ultratrace levels of bismuth in the rat II. Interaction of

Animals Bismuth Cell Nucleus Cytosol Kidney Liver Male Rats Subcellular Fractions
Bismuth Environmental toxicology Metabolic pattern Radioisotopes Rat tissues

Journal

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
ISSN: 1878-3252
Titre abrégé: J Trace Elem Med Biol
Pays: Germany
ID NLM: 9508274

Informations de publication

Date de publication:
Dec 2021
Historique:
received: 07 11 2020
revised: 23 02 2021
accepted: 29 03 2021
pubmed: 29 4 2021
medline: 17 2 2022
entrez: 28 4 2021
Statut: ppublish

Résumé

Knowledge on Bi metabolism in laboratory animals refers to studies at "extreme" exposures, i.e. pharmacologically relevant high-doses (mg kg Animals were intraperitoneally injected with 0.8 μg Bi kg At 24 h post injection the kidney contained by far the highest Bi concentration (10 ng g At the best of our knowledge the present paper represents the first in vivo study, on the basis of an environmental toxicology approach, aiming at describing retention and binding of Bi in the rat at tissue, intracellular and molecular levels.

Sections du résumé

BACKGROUND BACKGROUND
Knowledge on Bi metabolism in laboratory animals refers to studies at "extreme" exposures, i.e. pharmacologically relevant high-doses (mg kg
METHODS METHODS
Animals were intraperitoneally injected with 0.8 μg Bi kg
MAIN FINDINGS RESULTS
At 24 h post injection the kidney contained by far the highest Bi concentration (10 ng g
CONCLUSIONS CONCLUSIONS
At the best of our knowledge the present paper represents the first in vivo study, on the basis of an environmental toxicology approach, aiming at describing retention and binding of Bi in the rat at tissue, intracellular and molecular levels.

Identifiants

DOI: 10.1016/j.jtemb.2021.126752 PMID: 33906785
pubmed: 33906785
pii: S0946-672X(21)00042-0
doi: 10.1016/j.jtemb.2021.126752
pii:
doi:

Substances chimiques

Bismuth U015TT5I8H

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

126752

Informations de copyright

Copyright © 2021 Elsevier GmbH. All rights reserved.

Auteurs

Enrico Sabbioni (E)

Center for Advanced Studies and Technology (C.A.S.T.), "G. d'Annunzio" University of Chieti-Pescara, Via Luigi Polacchi 11, Chieti, I-66100, Italy; LASA, Department of Physics, Università Degli Studi di Milano and INFN-Milano, Via F.lli Cervi 201, Segrate, MI, I-20090, Italy.

Flavia Groppi (F)

Department of Physics, Università Degli Studi di Milano, Via Celoria 16, Milano, I-20133, Italy; LASA, Department of Physics, Università Degli Studi di Milano and INFN-Milano, Via F.lli Cervi 201, Segrate, MI, I-20090, Italy.

Mario Di Gioacchino (M)

Center for Advanced Studies and Technology (C.A.S.T.), "G. d'Annunzio" University of Chieti-Pescara, Via Luigi Polacchi 11, Chieti, I-66100, Italy; Institute of Clinical Immunotherapy and Advanced Biological Treatments, Piazza Pierangeli 1, Pescara, Italy; Rectorate of Leonardo da Vinci Telematic University, Largo San Rocco 11 Torrevecchia, Teatina, CH, Italy.

Claudia Petrarca (C)

Center for Advanced Studies and Technology (C.A.S.T.), "G. d'Annunzio" University of Chieti-Pescara, Via Luigi Polacchi 11, Chieti, I-66100, Italy; Department of Medicine and Aging Sciences, "G. d'Annunzio" University of Chieti-Pescara, via Luigi Polacchi 11, Chieti, I-66100, Italy.

Simone Manenti (S)

Department of Physics, Università Degli Studi di Milano, Via Celoria 16, Milano, I-20133, Italy; LASA, Department of Physics, Università Degli Studi di Milano and INFN-Milano, Via F.lli Cervi 201, Segrate, MI, I-20090, Italy. Electronic address: simone.manenti@unimi.it.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Metallobiochemistry of ultratrace levels of...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Bismuth › Metallobiochemistry of ultratrace levels of...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Noyau de la cellule › Metallobiochemistry of ultratrace levels of...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Cytosol › Metallobiochemistry of ultratrace levels of...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Metallobiochemistry of ultratrace levels of...
questionsmedicales.fr › Système digestif › Foie › Metallobiochemistry of ultratrace levels of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Metallobiochemistry of ultratrace levels of...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Metallobiochemistry of ultratrace levels of...