Unusual side effects of levetiracetam.
drug interactions
drugs and medicines
drugs: CNS (not psychiatric)
memory disorders
neurology (drugs and medicines)
Journal
BMJ case reports
ISSN: 1757-790X
Titre abrégé: BMJ Case Rep
Pays: England
ID NLM: 101526291
Informations de publication
Date de publication:
26 Apr 2021
26 Apr 2021
Historique:
entrez:
28
4
2021
pubmed:
29
4
2021
medline:
15
5
2021
Statut:
epublish
Résumé
We present a 75-year-old man who was admitted to our hospital due to 4 months of general deterioration, gait disturbance and cognition impairment which appeared very close to the start of levetiracetam (LEV) as a new antiepileptic drug. Brain CT shows central and less peripheral atrophy of brain, and diagnosis of normal pressure hydrocephalus was raised; however, removal of 30 cc of cerebrospinal fluid (CSF) by lumbar puncture in order to amend walking did not lead to gait improvement. After excluding metabolic, vascular, infection, inflammatory and other reasons explaining his status. Thinking that may be any correlation between LEV added in the last months and his clinical condition, we stopped LEV. Several days after that, there is marked improvement in his general sensation, alertness and cognitive status and there is marked improvement in walking balance to the point of being able to walk without the use of walker or cane or help from other person. Certain cognitive impairment and gait difficulties are not known as side effects of LEV treatment.
Identifiants
pubmed: 33906894
pii: 14/4/e242496
doi: 10.1136/bcr-2021-242496
pmc: PMC8076925
pii:
doi:
Substances chimiques
Anticonvulsants
0
Levetiracetam
44YRR34555
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Commentaires et corrections
Type : RepublishedIn
Informations de copyright
© BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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