Efficacy of autologous platelet-rich plasma in treating patients with burn wounds: A protocol for systematic review and meta-analysis.
Journal
Medicine
ISSN: 1536-5964
Titre abrégé: Medicine (Baltimore)
Pays: United States
ID NLM: 2985248R
Informations de publication
Date de publication:
30 Apr 2021
30 Apr 2021
Historique:
received:
01
04
2021
accepted:
05
04
2021
entrez:
28
4
2021
pubmed:
29
4
2021
medline:
5
5
2021
Statut:
ppublish
Résumé
Burns are still regarded among severe health problems related to high morbidity and mortality rates globally. In essence, health problems associated with burns can cause significant economic burden to society. Regardless of treatment available options, no best treatment was considered adequate for treating severe burns. In particular, only a few studies have focused on the effect of autologous platelet-rich plasma to treat burn wounds. The present study aim to systematically review existing literature to examine the effectiveness and safety of autologous platelet-rich plasma (PRP) to treat burn wounds. For this study, we will conduct a systematic search using MEDLINE, EMBASE, the Cochrane Library, Web of Science, CINAHL, as well as Scopus to discover randomised controlled trials (RCTs) for the examination of effectiveness and safety of autologous PRP to treat burn wounds from their inception to March 2021 with no language restrictions. Additionally, we will search Google Scholar, ClinicalTrials.gov, as well as the reference lists of studies considered in the research to ascertain possibly eligible studies. We used two independent authors to evaluate studies for inclusion and conduct data extraction. We intend to assess study bias and quality utilizing the Cochrane Collaboration's Risk of Bias Tool 2.0. Also, we will pool study results using the fixed-effects model or random-effects model. Finally, any disagreements emanating from the process will be addressed through discussion or using a third author to mediate situations leading to disagreement. The study aims at assessing the effectiveness and safety of autologous PRP for treating burn wounds. The study will provide specific substantiation to assess autologous PRP's effectiveness and safety in treating patients with burn wounds. The study does not require ethical approval since no published studies are used in it. March 29, 2021.osf.io/74z5u. (https://osf.io/74z5u/).
Sections du résumé
BACKGROUND
BACKGROUND
Burns are still regarded among severe health problems related to high morbidity and mortality rates globally. In essence, health problems associated with burns can cause significant economic burden to society. Regardless of treatment available options, no best treatment was considered adequate for treating severe burns. In particular, only a few studies have focused on the effect of autologous platelet-rich plasma to treat burn wounds. The present study aim to systematically review existing literature to examine the effectiveness and safety of autologous platelet-rich plasma (PRP) to treat burn wounds.
METHODS
METHODS
For this study, we will conduct a systematic search using MEDLINE, EMBASE, the Cochrane Library, Web of Science, CINAHL, as well as Scopus to discover randomised controlled trials (RCTs) for the examination of effectiveness and safety of autologous PRP to treat burn wounds from their inception to March 2021 with no language restrictions. Additionally, we will search Google Scholar, ClinicalTrials.gov, as well as the reference lists of studies considered in the research to ascertain possibly eligible studies. We used two independent authors to evaluate studies for inclusion and conduct data extraction. We intend to assess study bias and quality utilizing the Cochrane Collaboration's Risk of Bias Tool 2.0. Also, we will pool study results using the fixed-effects model or random-effects model. Finally, any disagreements emanating from the process will be addressed through discussion or using a third author to mediate situations leading to disagreement.
RESULTS
RESULTS
The study aims at assessing the effectiveness and safety of autologous PRP for treating burn wounds.
CONCLUSION
CONCLUSIONS
The study will provide specific substantiation to assess autologous PRP's effectiveness and safety in treating patients with burn wounds.
ETHICS AND DISSEMINATION
BACKGROUND
The study does not require ethical approval since no published studies are used in it.
OSF REGISTRATION NUMBER
UNASSIGNED
March 29, 2021.osf.io/74z5u. (https://osf.io/74z5u/).
Identifiants
pubmed: 33907125
doi: 10.1097/MD.0000000000025650
pii: 00005792-202104300-00040
pmc: PMC8084026
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e25650Subventions
Organisme : The Natural Science Foundation of Guangdong Province
ID : 2018A030310028
Organisme : China Postdoctoral Science Foundation
ID : 2019M652964
Informations de copyright
Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to disclose.
Références
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