Interferon lambda in inflammation and autoimmune rheumatic diseases.
Animals
Antiviral Agents
/ immunology
Autoimmune Diseases
/ immunology
Clinical Trials as Topic
Cytokines
Humans
Immunity
/ immunology
Immunity, Innate
/ immunology
Inflammation
/ drug therapy
Interferon Type I
/ immunology
Interferons
/ immunology
Lupus Erythematosus, Systemic
/ immunology
Mice
Rheumatic Diseases
/ immunology
Signal Transduction
/ immunology
Interferon Lambda
Journal
Nature reviews. Rheumatology
ISSN: 1759-4804
Titre abrégé: Nat Rev Rheumatol
Pays: United States
ID NLM: 101500080
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
accepted:
18
03
2021
pubmed:
29
4
2021
medline:
26
8
2021
entrez:
28
4
2021
Statut:
ppublish
Résumé
Interferons are potent antiviral cytokines that modulate immunity in response to infection or other danger signals. In addition to their antiviral functions, type I interferons (IFNα and IFNβ) are important in the pathogenesis of autoimmune diseases. Type III interferons (IFNλs) were initially described as a specialized system that inhibits viral replication at epithelial barrier surfaces while limiting inflammatory damage. However, evidence now suggests that type III interferons have complex effects on both innate and adaptive immune responses and might also be pathogenic in systemic autoimmune diseases. Concentrations of IFNλs are increased in blood and tissues in a number of autoimmune rheumatic diseases, including systemic lupus erythematosus, and are further associated with specific clinical and laboratory parameters. This Review is aimed at providing a critical evaluation of the current literature on IFNλ biology and how type III interferons might contribute to immune dysregulation and tissue damage in autoimmunity. The potential effects of type III interferons on treatment strategies for autoimmune rheumatic diseases, such as interferon blockade, are also considered.
Identifiants
pubmed: 33907323
doi: 10.1038/s41584-021-00606-1
pii: 10.1038/s41584-021-00606-1
pmc: PMC8077192
doi:
Substances chimiques
Antiviral Agents
0
Cytokines
0
Interferon Type I
0
Interferons
9008-11-1
Interferon Lambda
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
349-362Références
Genes Immun. 2007 Jan;8(1):13-20
pubmed: 17082759
Expert Rev Clin Immunol. 2016;12(2):95-8
pubmed: 26786849
J Exp Med. 2014 Sep 22;211(10):1969-76
pubmed: 25180061
Ann Rheum Dis. 2020 Mar;79(3):347-355
pubmed: 31871140
Science. 2015 Jan 16;347(6219):269-73
pubmed: 25431489
N Engl J Med. 2012 Aug 9;367(6):508-19
pubmed: 22873531
J Virol. 2017 Mar 13;91(7):
pubmed: 28077655
Nat Rev Immunol. 2019 Oct;19(10):614-625
pubmed: 31201377
N Engl J Med. 2020 Oct 15;383(16):1511-1521
pubmed: 33053283
Autoimmunity. 2015;48(7):429-33
pubmed: 26057401
J Invest Dermatol. 2015 Dec;135(12):2935-2943
pubmed: 26288353
PLoS One. 2010 Dec 08;5(12):e15200
pubmed: 21170333
N Engl J Med. 2012 Aug 9;367(6):495-507
pubmed: 22873530
Lancet. 2018 Jun 23;391(10139):2503-2512
pubmed: 29908669
Hum Immunol. 2014 Sep;75(9):996-1000
pubmed: 24994459
J Leukoc Biol. 2015 Oct;98(4):623-30
pubmed: 26130701
J Immunol. 2012 Sep 15;189(6):2735-45
pubmed: 22891284
Blood. 2011 Feb 24;117(8):2385-95
pubmed: 21190998
Ann Rheum Dis. 2005 Dec;64(12):1780-2
pubmed: 15878901
Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2610-5
pubmed: 12604793
Sci Immunol. 2017 Oct 6;2(16):
pubmed: 28986419
J Pathol. 2017 Sep;243(1):111-122
pubmed: 28678391
J Immunol. 2014 Apr 15;192(8):3596-606
pubmed: 24646741
Eur J Clin Invest. 2012 Jan;42(1):61-9
pubmed: 21707611
Immunity. 2019 Sep 17;51(3):451-464.e6
pubmed: 31471108
Lancet. 2018 Jun 23;391(10139):2513-2524
pubmed: 29908670
J Med Genet. 2013 Dec;50(12):812-8
pubmed: 24070858
Ann Rheum Dis. 2013 May;72(5):776-80
pubmed: 23434571
Rheumatology (Oxford). 2016 Oct;55(10):1901-5
pubmed: 27354683
N Engl J Med. 2014 Jun 19;370(25):2377-86
pubmed: 24941177
Reumatologia. 2020;58(4):221-230
pubmed: 32921829
Arthritis Res Ther. 2012 Oct 19;14(5):R228
pubmed: 23078630
J Immunol. 2017 Aug 1;199(3):1012-1020
pubmed: 28637903
Cancer Res. 2006 Apr 15;66(8):4468-77
pubmed: 16618774
Elife. 2018 Apr 13;7:
pubmed: 29651984
Curr Opin Immunol. 2017 Feb;44:20-25
pubmed: 27855321
Nat Med. 2016 Feb;22(2):146-53
pubmed: 26779811
Lancet. 2018 Jul 21;392(10143):222-231
pubmed: 30043749
Cell Death Dis. 2020 Jun 2;11(6):414
pubmed: 32488049
Arthritis Res Ther. 2011 Jun 16;13(3):R88
pubmed: 21679442
J Exp Med. 2015 Jun 1;212(6):845-53
pubmed: 25941255
Nat Immunol. 2015 Aug;16(8):802-9
pubmed: 26194286
Eur J Immunol. 2015 Jan;45(1):250-9
pubmed: 25316442
Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):31-40
pubmed: 28421993
Rheumatology (Oxford). 2014 Apr;53(4):686-95
pubmed: 24357810
N Engl J Med. 2017 Feb 16;376(7):652-662
pubmed: 28199814
Sci Transl Med. 2013 Sep 25;5(204):204ra129
pubmed: 24068736
Nat Rev Rheumatol. 2020 Mar;16(3):155-166
pubmed: 32034323
Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2770-5
pubmed: 16477017
J Invest Dermatol. 2011 Jan;131(1):133-40
pubmed: 20720564
Sci Rep. 2019 Oct 16;9(1):14834
pubmed: 31619697
Lupus. 2021 Feb;30(2):315-319
pubmed: 33086919
Science. 2020 Aug 7;369(6504):712-717
pubmed: 32527928
J Immunol. 2014 Jun 15;192(12):5459-68
pubmed: 24907379
Nat Rev Rheumatol. 2019 Jul;15(7):403-412
pubmed: 31165780
J Immunol. 2008 Feb 15;180(4):2474-85
pubmed: 18250457
Nat Immunol. 2017 Jul 19;18(8):832-842
pubmed: 28722725
Immunity. 2017 May 16;46(5):875-890.e6
pubmed: 28514692
Arthritis Rheumatol. 2021 May;73(5):858-865
pubmed: 33258553
Cell Rep. 2020 Oct 6;33(1):108211
pubmed: 33027651
Arthritis Res Ther. 2013 Oct 29;15(5):R170
pubmed: 24286242
J Clin Invest. 2019 Mar 1;129(3):1359-1371
pubmed: 30645203
Nat Immunol. 2019 Aug;20(8):1035-1045
pubmed: 31235953
Curr Opin Rheumatol. 2020 Jan;32(1):64-70
pubmed: 31644465
Nat Immunol. 2017 Oct;18(10):1084-1093
pubmed: 28846084
Autoimmunity. 2017 Mar;50(2):82-85
pubmed: 28263098
Ann Rheum Dis. 2014 Jan;73(1):256-62
pubmed: 23434567
J Invest Dermatol. 2015 Oct;135(10):2402-2409
pubmed: 25993119
J Leukoc Biol. 2018 Sep;104(3):499-514
pubmed: 29999544
Arthritis Rheum. 2005 Jan;52(1):201-11
pubmed: 15641052
Nat Immunol. 2019 Jul;20(7):915-927
pubmed: 31110316
J Vis Exp. 2016 Mar 14;(109):
pubmed: 27023275
Cytokine. 2016 Oct;86:124-131
pubmed: 27513213
Genes Immun. 2007 Apr;8(3):254-61
pubmed: 17361203
Science. 2020 Aug 7;369(6504):706-712
pubmed: 32527925
J Immunol. 2004 Aug 15;173(4):2815-24
pubmed: 15295000
PLoS Pathog. 2016 Apr 29;12(4):e1005600
pubmed: 27128797
J Invest Dermatol. 2017 Jul;137(7):1484-1492
pubmed: 28351661
Science. 2020 Oct 23;370(6515):
pubmed: 32972996
Genes Immun. 2009 Mar;10(2):125-31
pubmed: 18987645
Arthritis Rheum. 2013 Feb;65(2):447-56
pubmed: 23203821
N Engl J Med. 2020 Jan 16;382(3):211-221
pubmed: 31851795
Clin Exp Immunol. 2016 Dec;186(3):304-312
pubmed: 27613139
Lupus Sci Med. 2016 Nov 22;3(1):e000170
pubmed: 27933198
EMBO Mol Med. 2011 Jun;3(6):348-61
pubmed: 21538995
J Virol. 2009 Apr;83(8):3834-42
pubmed: 19193806
Nat Genet. 2013 Feb;45(2):164-71
pubmed: 23291588
Arthritis Rheumatol. 2014 Mar;66(3):694-706
pubmed: 24574230
Arthritis Res Ther. 2019 Apr 29;21(1):107
pubmed: 31036046
J Biol Chem. 2017 Oct 27;292(43):17928-17938
pubmed: 28900038
J Exp Med. 2014 Sep 22;211(10):1977-91
pubmed: 25180065
Lancet. 2019 Jun 8;393(10188):2303-2311
pubmed: 31130260
PLoS Pathog. 2018 Nov 28;14(11):e1007420
pubmed: 30485383
Immunity. 2019 Apr 16;50(4):907-923
pubmed: 30995506
Arthritis Rheumatol. 2021 Mar;73(3):459-471
pubmed: 32909675
Arthritis Rheumatol. 2017 Mar;69(3):506-517
pubmed: 27723271
Arthritis Res Ther. 2014 Feb 24;16(1):R57
pubmed: 24559157
Nat Rev Rheumatol. 2019 Sep;15(9):519-532
pubmed: 31399711
Front Immunol. 2017 Nov 28;8:1661
pubmed: 29234323
J Exp Med. 2016 Nov 14;213(12):2527-2538
pubmed: 27821552
PLoS Pathog. 2015 Apr 07;11(4):e1004782
pubmed: 25849543
Nature. 2020 Oct;586(7830):560-566
pubmed: 32854108
PLoS Pathog. 2008 Mar 14;4(3):e1000017
pubmed: 18369468
Arthritis Rheumatol. 2016 Jul;68(7):1769-79
pubmed: 26866822
Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9822-7
pubmed: 17517620
Gastroenterology. 2017 Jul;153(1):123-138.e8
pubmed: 28342759
PLoS Pathog. 2020 Apr 30;16(4):e1008515
pubmed: 32353085
Front Immunol. 2017 Oct 16;8:1302
pubmed: 29085367
Nat Rev Immunol. 2014 Jan;14(1):36-49
pubmed: 24362405
Tohoku J Exp Med. 2017;241(2):89-95
pubmed: 28154345
Arthritis Rheumatol. 2017 Jan;69(1):148-160
pubmed: 27429362
Arthritis Rheum. 2003 Sep;48(9):2524-32
pubmed: 13130472
Ann Rheum Dis. 2016 Nov;75(11):1909-1916
pubmed: 27009916
Autoimmunity. 2013 Feb;46(1):40-3
pubmed: 23039206
J Exp Med. 2001 Dec 17;194(12):1823-34
pubmed: 11748283
Sci Adv. 2019 Jul 10;5(7):eaav9019
pubmed: 31309143
Arthritis Res Ther. 2018 Aug 29;20(1):193
pubmed: 30157968
Annu Rev Pathol. 2019 Jan 24;14:369-393
pubmed: 30332560
Sci Transl Med. 2015 Apr 22;7(284):284ra59
pubmed: 25904743
Lancet. 2017 Jul 29;390(10093):457-468
pubmed: 28629665
J Clin Rheumatol. 2017 Oct;23(7):368-375
pubmed: 28937472
Nat Immunol. 2003 Jan;4(1):63-8
pubmed: 12469119
Nat Commun. 2019 Jan 17;10(1):280
pubmed: 30655513
J Hepatol. 2014 Dec;61(6):1238-46
pubmed: 25064437
EMBO Mol Med. 2013 Jul;5(7):1035-50
pubmed: 23681607
Arthritis Res Ther. 2017 Jun 15;19(1):139
pubmed: 28619037
Front Immunol. 2019 Nov 19;10:2674
pubmed: 31798594
Nat Immunol. 2019 May;20(5):593-601
pubmed: 30886417
Ann Rheum Dis. 2016 Jan;75(1):196-202
pubmed: 26038091
Bone Res. 2018 Apr 27;6:15
pubmed: 29736302
N Engl J Med. 2016 Mar 31;374(13):1243-52
pubmed: 27028914
Nat Immunol. 2003 Jan;4(1):69-77
pubmed: 12483210
J Exp Med. 2014 May 5;211(5):857-68
pubmed: 24752298
Arthritis Res Ther. 2020 Jun 5;22(1):130
pubmed: 32503683
PLoS One. 2011;6(7):e22200
pubmed: 21779393
J Leukoc Biol. 2016 Jan;99(1):107-19
pubmed: 26382296
Arthritis Rheum. 2005 May;52(5):1534-44
pubmed: 15880807
J Interferon Cytokine Res. 2016 Dec;36(12):671-680
pubmed: 27617757
PLoS One. 2016 Oct 17;11(10):e0164563
pubmed: 27749900
Immunity. 2015 Jul 21;43(1):15-28
pubmed: 26200010
PLoS One. 2012;7(4):e35902
pubmed: 22558263
Blood. 2006 Jun 1;107(11):4417-23
pubmed: 16478884
Nat Rev Drug Discov. 2017 Dec;16(12):843-862
pubmed: 29104284
Proc Natl Acad Sci U S A. 2020 Mar 10;117(10):5409-5419
pubmed: 32094169
Annu Rev Immunol. 2014;32:513-45
pubmed: 24555472
PLoS Pathog. 2014 Dec 11;10(12):e1004556
pubmed: 25503988
J Biol Chem. 2017 May 5;292(18):7295-7303
pubmed: 28289095
J Immunol. 2020 Sep 1;205(5):1268-1280
pubmed: 32690660
J Exp Med. 2003 Mar 17;197(6):711-23
pubmed: 12642603