Pharmacological Management of Gastro-Esophageal Reflux Disease: An Update of the State-of-the-Art.
PPI-refractory patients
bile acid sequestrant drug
esophageal mucosal resistance
medical management of GERD
mucosal protective agents
potassium competitive acid blockers
proton pump inhibitors
Journal
Drug design, development and therapy
ISSN: 1177-8881
Titre abrégé: Drug Des Devel Ther
Pays: New Zealand
ID NLM: 101475745
Informations de publication
Date de publication:
2021
2021
Historique:
received:
18
02
2021
accepted:
06
04
2021
entrez:
28
4
2021
pubmed:
29
4
2021
medline:
28
10
2021
Statut:
epublish
Résumé
Gastro-esophageal reflux disease (GERD) is a highly prevalent, chronic disorder, whose knowledge remains limited and the management of these patients changes continuously. This review provides a summary of the most recent advancements in the pathogenesis of this disease and the new drugs introduced into the market to overcome some of the unmet needs of traditional therapies. Nowadays, the most fruitful diagnostic examinations are 24-hour impedance-pH monitoring, which allows us to separate true NERD from esophageal functional disorders and high-resolution manometry, which helps to exclude the existence of motility disorders sharing the same symptoms of GERD. Proton pump inhibitors (PPIs) remain the first-choice therapy in the treatment of GERD, but a consistent proportion of these patients continue to experience symptoms despite their intake. These cases pertain mainly to the subpopulation with non-erosive reflux disease (NERD) and represent very challenging clinical situations, because it is mandatory to understand the reasons for PPI failure. The management of these difficult patients requires necessarily to test them and avoid the use of empiric treatments that are often unsuccessful, costly and potentially dangerous. Recently, several new drugs have been used to increase the defensive properties of this mucosa with promising results in randomized clinical trials.
Identifiants
pubmed: 33907381
doi: 10.2147/DDDT.S306371
pii: 306371
pmc: PMC8064680
doi:
Substances chimiques
Proton Pump Inhibitors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1609-1621Informations de copyright
© 2021 Savarino et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
Références
Am J Gastroenterol. 2011 Aug;106(8):1419-25; quiz 1426
pubmed: 21537361
Clin Exp Gastroenterol. 2012;5:103-7
pubmed: 22767997
World J Gastroenterol. 2018 Apr 14;24(14):1550-1561
pubmed: 29662293
Scand J Gastroenterol. 2005 Mar;40(3):275-85
pubmed: 15932168
Dis Esophagus. 2012 Jul;25(5):373-80
pubmed: 22050449
Gut. 2012 Sep;61(9):1340-54
pubmed: 22684483
Neurogastroenterol Motil. 2018 Jun;30(6):e13302
pubmed: 29441683
Clin Gastroenterol Hepatol. 2004 Aug;2(8):665-8
pubmed: 15290658
Expert Rev Clin Pharmacol. 2020 Apr;13(4):437-449
pubmed: 32253948
Gastroenterology. 2006 Mar;130(3):639-49
pubmed: 16530504
Am J Physiol Gastrointest Liver Physiol. 2015 Jun 15;308(12):G975-80
pubmed: 25907692
Aliment Pharmacol Ther. 2016 Jan;43(2):240-51
pubmed: 26559637
Am J Gastroenterol. 2005 Oct;100(10):2299-306
pubmed: 16181384
Am J Gastroenterol. 2006 Aug;101(8):1900-20; quiz 1943
pubmed: 16928254
Gastroenterol Res Pract. 2014;2014:307805
pubmed: 25389436
Aliment Pharmacol Ther. 2017 Mar;45(5):631-642
pubmed: 28116754
Aliment Pharmacol Ther. 2011 Jul;34(1):59-66
pubmed: 21535446
Gut. 2010 Apr;59(4):441-51
pubmed: 19651625
Am J Gastroenterol. 2013 Jul;108(7):1058-64
pubmed: 23629599
Br J Surg. 2009 Sep;96(9):1023-30
pubmed: 19672931
J Gastroenterol. 2017 Apr;52(4):444-451
pubmed: 27241210
Neurogastroenterol Motil. 2017 Oct;29(10):1-15
pubmed: 28370768
Neurogastroenterol Motil. 2012 Aug;24(8):747-57, e350
pubmed: 22309489
Gastroenterology. 2021 Jan;160(1):19-20
pubmed: 33157096
Cochrane Database Syst Rev. 2010 Nov 10;(11):CD002095
pubmed: 21069670
Expert Rev Clin Pharmacol. 2018 Nov;11(11):1123-1134
pubmed: 30295105
Gastroenterology. 2017 Nov;153(5):1230-1239
pubmed: 28734832
Expert Opin Drug Metab Toxicol. 2012 Oct;8(10):1327-35
pubmed: 22985444
Dig Liver Dis. 2011 Dec;43(12):940-5
pubmed: 21944835
Gut. 2011 Nov;60(11):1473-8
pubmed: 21508423
Aliment Pharmacol Ther. 2020 Aug;52(3):442-448
pubmed: 32548849
Gastroenterology. 1981 Feb;80(2):285-91
pubmed: 7450419
Dig Dis Sci. 2011 Apr;56(4):1099-106
pubmed: 20737211
Am J Gastroenterol. 2016 Feb;111(2):217-24
pubmed: 26753892
N Engl J Med. 2019 Oct 17;381(16):1513-1523
pubmed: 31618539
Expert Opin Pharmacother. 2017 Aug;18(11):1145-1152
pubmed: 28657473
N Engl J Med. 1995 Oct 26;333(17):1106-10
pubmed: 7565948
Am J Gastroenterol. 2004 Jun;99(6):981-8
pubmed: 15180713
Ann Gastroenterol. 2018 Jan-Feb;31(1):1-7
pubmed: 29333061
Aliment Pharmacol Ther. 2019 Jan;49(2):140-146
pubmed: 30589965
Clin Gastroenterol Hepatol. 2016 Jan;14(1):40-6
pubmed: 26122764
Neurogastroenterol Motil. 2013 Oct;25(10):783-99
pubmed: 23937353
Expert Opin Drug Metab Toxicol. 2016 Nov;12(11):1333-1341
pubmed: 27428571
Am J Gastroenterol. 2012 Nov;107(11):1662-7
pubmed: 21625270
Dig Dis Sci. 2017 Aug;62(8):1881-1889
pubmed: 28550489
Gut. 2009 Sep;58(9):1185-91
pubmed: 19460766
J Gastroenterol. 2013 Apr;48(4):473-82
pubmed: 23001252
Am J Physiol Gastrointest Liver Physiol. 2003 Feb;284(2):G242-7
pubmed: 12388187
Dig Dis Sci. 2021 Jan;66(1):19-28
pubmed: 32095968
Gut. 1999 Aug;45(2):172-80
pubmed: 10403727
J Neurogastroenterol Motil. 2015 Mar 30;21(2):265-72
pubmed: 25843078
Neurogastroenterol Motil. 2017 Mar;29(3):
pubmed: 27620303
Dig Liver Dis. 2016 Aug;48(8):851-9
pubmed: 27321544
Clin Gastroenterol Hepatol. 2004 Aug;2(8):656-64
pubmed: 15290657
Gut. 2008 Oct;57(10):1354-9
pubmed: 18424568
Nat Rev Gastroenterol Hepatol. 2017 Nov;14(11):665-676
pubmed: 28951582
World J Gastroenterol. 2014 Mar 7;20(9):2412-9
pubmed: 24605040
Curr Opin Pharmacol. 2011 Dec;11(6):630-3
pubmed: 22036168
Aliment Pharmacol Ther. 2003 Feb;17(3):343-51
pubmed: 12562446
Dis Esophagus. 2017 Feb 1;30(2):1-9
pubmed: 27862680
United European Gastroenterol J. 2018 Aug;6(7):981-989
pubmed: 30228885
Aliment Pharmacol Ther. 2016 Apr;43(8):899-909
pubmed: 26909885
Expert Rev Gastroenterol Hepatol. 2019 Sep;13(9):827-838
pubmed: 31322443
Curr Gastroenterol Rep. 2004 Jun;6(3):213-9
pubmed: 15128488
Therap Adv Gastroenterol. 2018 Jan 09;11:1756283X17745776
pubmed: 29383028
Dig Liver Dis. 2020 Aug;52(8):842-852
pubmed: 32513631
Aliment Pharmacol Ther. 2010 Sep;32(6):720-37
pubmed: 20662774
Eur J Gastroenterol Hepatol. 2014 Jan;26(1):6-10
pubmed: 24025979
Pharmacol Res. 2009 Mar;59(3):135-53
pubmed: 18977444
Br J Surg. 2006 Dec;93(12):1483-7
pubmed: 17051602
Aliment Pharmacol Ther. 1998 Dec;12(12):1241-7
pubmed: 9882033
Neurogastroenterol Motil. 2020 Dec;32(12):e13919
pubmed: 32573065
Dig Liver Dis. 2020 Dec;52(12):1413-1420
pubmed: 33097427
Neurogastroenterol Motil. 2012 Aug;24(8):697-704
pubmed: 22783985
Gastroenterology. 2020 Jun;158(8):2093-2103
pubmed: 32092310
Ann N Y Acad Sci. 2014 Sep;1325:23-39
pubmed: 25266012
Neurogastroenterol Motil. 2014 May;26(5):670-8
pubmed: 24533896
Expert Opin Pharmacother. 2017 Sep;18(13):1333-1343
pubmed: 28754071
Gut. 2019 Nov;68(11):1928-1941
pubmed: 31375601
Gut. 2005 May;54(5):710-7
pubmed: 15831922
Gut. 1997 May;40(5):587-90
pubmed: 9203934
Clin Transl Gastroenterol. 2015 Jun 25;6:e94
pubmed: 26111126
Neurogastroenterol Motil. 2015 Sep;27(9):1202-13
pubmed: 26053301
Am J Gastroenterol. 2018 Jul;113(7):980-986
pubmed: 29686276
Aliment Pharmacol Ther. 2015 Sep;42(6):685-95
pubmed: 26201312
Early Hum Dev. 2021 Jan;152:105248
pubmed: 33188979
Digestion. 2020;101(2):174-183
pubmed: 30897577
Neurogastroenterol Motil. 2014 Feb;26(2):187-95
pubmed: 24188252
Aliment Pharmacol Ther. 2003 Jan;17(2):243-51
pubmed: 12534409
Cochrane Database Syst Rev. 2007 Apr 18;(2):CD003244
pubmed: 17443524
Digestion. 2017;95(2):156-161
pubmed: 28190016
Surg Endosc. 2013 Aug;27(8):2940-6
pubmed: 23436097
Gastroenterology. 2016 Feb 15;:
pubmed: 27144625
Nat Rev Gastroenterol Hepatol. 2013 Jun;10(6):371-80
pubmed: 23528345
Gastroenterology. 2017 Mar;152(4):706-715
pubmed: 28257716
Ann N Y Acad Sci. 2020 Dec;1482(1):193-212
pubmed: 32935346
Rheumatology (Oxford). 2013 Jun;52(6):1095-100
pubmed: 23382360
Am J Gastroenterol. 2016 Dec;111(12):1711-1717
pubmed: 27644732
Aliment Pharmacol Ther. 2003 Feb;17(3):353-9
pubmed: 12562447
Gastroenterology. 2001 Oct;121(4):775-83
pubmed: 11606490
Dig Dis Sci. 2019 Mar;64(3):815-822
pubmed: 30415407