Advanced oxidation protein products aggravate age‑related bone loss by increasing sclerostin expression in osteocytes via ROS‑dependent downregulation of Sirt1.
Acetophenones
/ pharmacology
Acetylcysteine
/ pharmacology
Adaptor Proteins, Signal Transducing
/ metabolism
Advanced Oxidation Protein Products
/ toxicity
Animals
Bone Resorption
/ complications
Cell Line
Down-Regulation
/ drug effects
Male
Mice, Inbred C57BL
Osteocytes
/ drug effects
Osteogenesis
/ drug effects
Osteoporosis
/ genetics
Reactive Oxygen Species
/ metabolism
Sirtuin 1
/ genetics
advanced oxidation protein products
age‑related bone loss
oxidative stress
sclerostin
sirtuin 1
Journal
International journal of molecular medicine
ISSN: 1791-244X
Titre abrégé: Int J Mol Med
Pays: Greece
ID NLM: 9810955
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
11
01
2021
accepted:
11
03
2021
entrez:
28
4
2021
pubmed:
29
4
2021
medline:
12
11
2021
Statut:
ppublish
Résumé
Advanced oxidation protein products (AOPPs) induce intracellular oxidative stress (OS) and are involved in numerous diseases. AOPPs accumulate with age, and our previous study revealed that AOPPs accelerated bone deterioration in aged rats. However, the underlying mechanism remains unknown. The present study demonstrated that AOPPs aggravated bone loss in aging male mice by increasing the resorptive activity and decreasing the formative activity of bone tissues. In addition,
Identifiants
pubmed: 33907818
doi: 10.3892/ijmm.2021.4941
pii: 108
doi:
pii:
Substances chimiques
Acetophenones
0
Adaptor Proteins, Signal Transducing
0
Advanced Oxidation Protein Products
0
Reactive Oxygen Species
0
Sost protein, mouse
0
acetovanillone
B6J7B9UDTR
Sirtuin 1
EC 3.5.1.-
Acetylcysteine
WYQ7N0BPYC
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM