African Immigrants in New York City with Hepatitis B-Related Hepatocellular Carcinoma Demonstrate High Morbidity and Mortality.
African immigrants
HBV-associated HCC
HCC epidemiology
Journal
Journal of immigrant and minority health
ISSN: 1557-1920
Titre abrégé: J Immigr Minor Health
Pays: United States
ID NLM: 101256527
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
accepted:
19
04
2021
pubmed:
29
4
2021
medline:
22
2
2022
entrez:
28
4
2021
Statut:
ppublish
Résumé
Guidelines recommend hepatitis B (HBV) testing in individuals from endemic areas, and if positive, screening for hepatocellular carcinoma (HCC). While screening programs are well established in the Asian immigrant population in New York City (NYC), less is known about the characteristics of HBV/HCC among the African immigrant community. A retrospective review was performed of HCC cases from 2005 to 2018 at our institution. Country of origin was not documented in the electronic medical record; therefore, African immigrant status was approximated using self-identified race/ethnicity, positive HBV status, and an online registry to determine country of origin based on last name. Surnames with the greatest prevalence or density in an African country were considered. Among 4400 patients with HCC, 472 identified as non-Hispanic Black; of these, 86 were HBV+. Based on surname, it was estimated that 33 individuals were likely immigrants from Africa. In this group, median age of HCC diagnosis was 48 years (IQR 43-55). In patients with an available date of HBV diagnosis (n = 24), 17 (71%) were unaware of their HBV status when they presented with HCC. Zero patients were diagnosed with HCC through routine screening, most patients (66%) were diagnosed upon imaging evaluation of symptoms. Twelve patients (36%) underwent resection or transplantation; the remaining 64% were ineligible for surgical treatment. Of the 26 patients with follow-up data, 18 (69%) died of disease or were critically ill at last encounter, and of these, 14 (77%) died within 1 year of HCC diagnosis. In conclusion, African immigrants in NYC with HBV/HCC are at high risk of HCC related mortality at a young age. Most were unaware of their hepatitis status at the time of HCC diagnosis. No patients were enrolled in routine HCC screening; the majority were diagnosed based on imaging obtained for symptoms. Most individuals presented with inoperable disease, and the majority died within months of diagnosis. Awareness of these findings may help healthcare providers improve patient outcomes.
Identifiants
pubmed: 33907933
doi: 10.1007/s10903-021-01205-8
pii: 10.1007/s10903-021-01205-8
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
327-333Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Références
Kulik L, El-Serag HB. Epidemiology and management of hepatocellular carcinoma. Gastroenterology. 2019;56(2):477–91.
doi: 10.1053/j.gastro.2018.08.065
De Martel C, Maucort-Boulch D, Plummer M, Franceschi S. World-wide relative contribution of hepatitis B and C viruses in hepatocellular carcinoma. Hepatology. 2015;62(4):1190–2000.
doi: 10.1002/hep.27969
El-Serag HB. Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology. 2012;142(6):1264–73.
doi: 10.1053/j.gastro.2011.12.061
Sharma S, Carballo M, Field JJ, Janssen HLA. Immigration and viral hepatitis. J Hepatol. 2015;63(2):515–22.
doi: 10.1016/j.jhep.2015.04.026
Zhang BH, Yang BH, Tang ZY. Randomized controlled trial of screening for hepatocellular carcinoma. J Cancer Res Clin Oncol. 2004;130(7):417–22.
doi: 10.1007/s00432-004-0552-0
Liaw YF, Sung JJ, Chow WC, et al. Lamivudine for patients with chronic hepatitis B and advanced liver disease. N Engl J Med. 2004;351(15):1521–31.
doi: 10.1056/NEJMoa033364
Chang ET, Keegan THM, Gomez SL, et al. The burden of liver cancer in Asians and Pacific Islanders in the Greater San Francisco Bay Area, 1990 through 2004. Cancer. 2007;109(10):2100–8.
doi: 10.1002/cncr.22642
Wan DW, Tzimas D, Smith JA, et al. Risk factors for early-onset and late-onset hepatocellular carcinoma in Asian immigrants with hepatitis B in the United States. Am J Gastroenterol. 2011;106(11):1994–2000.
doi: 10.1038/ajg.2011.302
Marrero JA, Kulik LM, Sirlin CB, et al. Diagnosis, staging, and management of hepatocellular carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases. Hepatology. 2018;68(2):723–50.
doi: 10.1002/hep.29913
Campbell J. Where African immigrants live in New York City. Council on Foreign Relations 2014. https://www.cfr.org/blog/where-african-immigrants-live-new-york-city .
Anderson M. African immigrant population in U.S. steadily climbs. Pew Research Center 2017. https://www.pewresearch.org/fact-tank/2017/02/14/african-immigrant-population-in-u-s-steadily-climbs/ .
Kew MC. Hepatocellular carcinoma in African Blacks: recent progress in etiology and pathogenesis. World J Hepatol. 2010;2(2):65–73.
doi: 10.4254/wjh.v2.i2.65
Surveillance standards for vaccine-preventable diseases. 2nd ed. Geneva: World Health Organization 2018. License: CC BY-NC-SA 3.0 IGO.
Zhang Y, Adnan M, Longley P, Maciejewski R. Exploring geo-genealogy using internet surname search histories. J Maps. 2013;9(4):481–6.
doi: 10.1080/17445647.2013.824391
Fitzgerald S, Chao J, Feferman Y, Perumalswami P, Sarpel U. Hepatitis B and hepatocellular carcinoma screening practices in Chinese and African immigrant-rich neighborhoods in New York City. J Racial Ethn Health Disparities. 2016;4:928–35.
doi: 10.1007/s40615-016-0296-y
Adland E, Jesuthasan G, Downs L, et al. Hepatitis virus (HCV) diagnosis and access to treatment in a UK cohort. BMC Infect Dis. 2018;18(1):461.
doi: 10.1186/s12879-018-3367-3
Ryan R, Vernon S, Lawrence G, Wilson S. Use of name recognition software, census data and multiple imputation to predict missing data on ethnicity: application to cancer registry records. BMC Med Inform Decis Mak. 2012;12(3)
Mateo P. A review of name-based ethnicity classification methods and their potential in population studies. Popul Space Place. 2007;13(4):243–63.
doi: 10.1002/psp.457
Kruse H, Dollmann J. Name-based measures of neighborhood compositions: how telling are neighbors’ names? Surv Res Methods. 2017;11(4):435–50.
Poston WC, Pavlik VN, Hyman DJ, Ogbonnaya K, Hanis CL, Haddock CK, Hyder ML, Foreyt JP. Genetic bottlenecks, perceived racism, and hypertension risk among African Americans and first-generation African immigrants. J Hum Hypertens. 2001;15:341–51.
doi: 10.1038/sj.jhh.1001174
National R. State, and selected local area vaccination coverage among adolescents aged 13–17 years—United States, 2016. MMWR Morb Mortal Wkly Rep. 2017;66(33):1–6.
Achievements in public health: hepatitis B vaccination—United States, 1982–2002. MMWR Morb Mortal Wkly Rep 2002;51(25):549–552, 563.
Hepatitis B vaccine mandates for childcare and K-12. Immunization Action Coalition 2019. https://www.immunize.org/laws/hepb.asp .
Akinyemiju T, Abera S, Ahmed M, et al. The burden of primary liver cancer and underlying etiologies from 1990 to 2015 at the global, regional, and national level: results from the Global Burden of Disease Study 2015. JAMA Oncol. 2017;3(12):1683–91.
doi: 10.1001/jamaoncol.2017.3055
Chen JD, Yang HI, Iloeje UH, et al. Carriers of inactive hepatitis B virus are still at risk for hepatocellular carcinoma and liver-related death. Gastroenterology. 2010;138(5):1747–54.
doi: 10.1053/j.gastro.2010.01.042
Beasley RP. Hepatitis B virus: the major etiology of hepatocellular carcinoma. Cancer. 1988;61(10):1942–56.
doi: 10.1002/1097-0142(19880515)61:10<1942::AID-CNCR2820611003>3.0.CO;2-J
Yang JD, Mohamed EA, Aziz AOA, et al. Characteristics, management, and outcomes of patients with hepatocellular carcinoma in Africa: a multicountry observational study from the Africa Liver Cancer Consortium. Lancet Gastroenterol Hepatol. 2017;2(2):103–11.
doi: 10.1016/S2468-1253(16)30161-3
Echejoh GO, Tanko MN, Manasseh AN, Ogala-Echejoh S, Ugoya SO, Mandong BM. Hepatocellular carcinoma in Jos, Nigeria. Niger J Med. 2008;17(2):210–3.
doi: 10.4314/njm.v17i2.37386
Kirk GD, Lesi OA, Mendy M, et al. The Gambia Liver Cancer Study: infection with hepatitis B and C and the risk of hepatocellular carcinoma in West Africa. Hepatology. 2004;39(1):211–9.
doi: 10.1002/hep.20027
Shire AM, Sandhu DS, Kaiya JK, et al. Viral hepatitis among Somali immigrants in Minnesota: association of hepatitis C with hepatocellular carcinoma. Mayo Clin Proc. 2012;87(1):17–24.
doi: 10.1016/j.mayocp.2011.08.001
Leclere FB, Jensen L, Biddlecom AE. Health care utilization, family context, and adaptation among immigrants to the United States. J Health Soc Behav. 1994;35(4):370–84.
doi: 10.2307/2137215
Berk ML, Schur CL, Chavez LR, Frankel M. Health care use among undocumented Latino immigrants. Health Aff. 2000;19(4):51–64.
doi: 10.1377/hlthaff.19.4.51
Adekeye OA, Adesuyi BF, Takon JG. Barriers to healthcare among African immigrants in Georgia, USA. J Immigr Minor Health. 2018;20:188–93.
doi: 10.1007/s10903-017-0549-9
Ogunwobi OO, Dubba O, Zhu L, Ilboudo A, Tan Y, Fraser MA, Ma GX. Hepatitis B virus screening and vaccination in first-generation African immigrants: a pilot study. J Community Health. 2019;44:1037–43.
doi: 10.1007/s10900-019-00668-z
Omenka OI, Watson DP, Hendrie HC. Understanding the healthcare experiences and needs of African immigrants in the United States: a scoping review. BMC Public Health. 2020;20:27–39.
doi: 10.1186/s12889-019-8127-9
Freeland C, Bodor S, Perera U, Cohen C. Barriers to hepatitis B screening and prevention for African immigrant populations in the United States: a qualitative study. Viruses. 2020;12:305–13.
doi: 10.3390/v12030305
Roayaie S, Jibara P, Tabrizian P, et al. The role of hepatic resection in the treatment of hepatocellular cancer. Hepatology. 2015;62(2):440–51.
doi: 10.1002/hep.27745
Massoumi H, Buchheit K, Gunturu S, Thlick J, Gaglio P. Clinical characteristics of chronic hepatitis B virus infection in immigrants from Sub-Saharan Africa. Hepatol Mon. 2017;17(4):e12305.
Jemal A, Ward EM, Johnson CJ, et al. Annual report to the nation on the status of cancer, 1974–2014, featuring survival. J Natl Cancer Inst. 2017;109(9):djx030.
doi: 10.1093/jnci/djx030
Davis GL, Dempster J, Meler JD, et al. Hepatocellular carcinoma: management of an increasingly common problem. Bayl Univ Med Center Proc. 2008;21(3):266–80.
doi: 10.1080/08998280.2008.11928410
Sobotka LA, Hinton A, Conteh LF. African Americans are less likely to receive curative treatment for hepatocellular carcinoma. World J Hepatol. 2018;10(11):849–55.
doi: 10.4254/wjh.v10.i11.849
Estevez J, Yang JD, Leong J, et al. Clinical features associated with survival outcome in African-American patients with hepatocellular carcinoma. Am J Gastroenterol. 2019;114(1):80–8.
doi: 10.1038/s41395-018-0261-y
Pollack H, Wang S, Wyatt L, et al. A comprehensive screening and treatment model for reducing disparities in hepatitis B. Health Aff (Millwood). 2011;30:1974–83.
doi: 10.1377/hlthaff.2011.0700